SEED Subsystem: Folate Biosynthesis in Cupriavidus basilensis FW507-4G11

Experiments:

Role Gene Name  
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) RR42_RS17240
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) RR42_RS01400
5-nucleotidase SurE (EC 3.1.3.5) RR42_RS13200
  RR42_RS32020
  RR42_RS32200
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12) No genes
ATPase component of general energizing module of ECF transporters No genes
Alternative Folylglutamate Synthase No genes
Alternative dihydrofolate reductase 2 No genes
Alternative dihydrofolate reductase 3 RR42_RS03160
Aminodeoxychorismate lyase (EC 4.1.3.38) RR42_RS16495
  RR42_RS17265
COG0488: ATPase components of ABC transporters with duplicated ATPase domains RR42_RS14685
Dihydrofolate reductase (EC 1.5.1.3) RR42_RS14745
Dihydrofolate synthase (EC 6.3.2.12) No genes
Dihydroneopterin aldolase (EC 4.1.2.25) RR42_RS01440
Dihydroneopterin triphosphate epimerase No genes
Dihydroneopterin triphosphate pyrophosphohydolase No genes
Dihydroneopterin triphosphate pyrophosphohydolase type 2 RR42_RS02470
Dihydropteroate synthase (EC 2.5.1.15) RR42_RS13480
FolM Alternative dihydrofolate reductase 1 RR42_RS01435
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB) No genes
Folate transporter 3 No genes
Folylpolyglutamate synthase (EC 6.3.2.17) No genes
Formate--tetrahydrofolate ligase (EC 6.3.4.3) No genes
GTP cyclohydrolase I (EC 3.5.4.16) type 1 RR42_RS34345
GTP cyclohydrolase I (EC 3.5.4.16) type 2 RR42_RS15000
Methionyl-tRNA formyltransferase (EC 2.1.2.9) RR42_RS20465
  RR42_RS23345
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) RR42_RS07345
Non functional Dihydropteroate synthase 2 No genes
Nucleoside triphosphate pyrophosphohydrolase MazG No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) No genes
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) RR42_RS17265
PqqC-like protein No genes
Putative DHNTP pyrophosphatase No genes
Related to Dihydropteroate synthase No genes
Serine hydroxymethyltransferase (EC 2.1.2.1) RR42_RS15485
Substrate-specific component FolT of folate ECF transporter No genes
Thymidine kinase (EC 2.7.1.21) No genes
Thymidylate synthase (EC 2.1.1.45) RR42_RS14740
Thymidylate synthase thyX (EC 2.1.1.-) No genes
Transaldolase (EC 2.2.1.2) RR42_RS13050
Transmembrane component of general energizing module of ECF transporters No genes
Xanthosine/inosine triphosphate pyrophosphatase No genes
alternate gene name: yzbB RR42_RS11610

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