SEED Subsystem: Coenzyme B12 biosynthesis in Burkholderia phytofirmans PsJN

Experiments:

Role Gene Name  
5,6-dimethylbenzimidazole synthase, flavin destructase family No genes
ATPase component CbiO of energizing module of cobalt ECF transporter No genes
Additional lipoprotein component of predicted cobalamin ECF transporter No genes
Additional substrate-specific component CbiN of cobalt ECF transporter No genes
Adenosylcobinamide amidohydrolase (EC 3.5.1.90) No genes
Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) BPHYT_RS04895
Adenosylcobinamide-phosphate synthase No genes
Aerobic cobaltochelatase CobS subunit (EC 6.6.1.2) BPHYT_RS21685
  BPHYT_RS26375
Aerobic cobaltochelatase CobT subunit (EC 6.6.1.2) BPHYT_RS21690
  BPHYT_RS26380
Alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.73) BPHYT_RS04875
  BPHYT_RS06750
CblX, a non-orthologous displasment for Alpha-ribazole-5'-phosphate phosphatase No genes
CblY, a non-orthologous displasment for Alpha-ribazole-5'-phosphate phosphatase No genes
CblZ, a non-orthologous displasment for Alpha-ribazole-5'-phosphate phosphatase No genes
ChlD component of cobalt chelatase involved in B12 biosynthesis BPHYT_RS24855
ChlI component of cobalt chelatase involved in B12 biosynthesis BPHYT_RS24850
Cob(I)alamin adenosyltransferase (EC 2.5.1.17) BPHYT_RS24825
Cob(I)alamin adenosyltransferase PduO (EC 2.5.1.17) No genes
Cob(II)alamin reductase No genes
CobN component of cobalt chelatase involved in B12 biosynthesis BPHYT_RS24845
CobW GTPase involved in cobalt insertion for B12 biosynthesis BPHYT_RS24840
Cobalamin biosynthesis protein CbiG BPHYT_RS26695
Cobalamin biosynthesis protein CobG BPHYT_RS26680
Cobalamin synthase No genes
Cobalamine-related hypothetical metal-binding protein CrdX No genes
Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) BPHYT_RS26690
Cobalt-precorrin-3b C17-methyltransferase BPHYT_RS26695
Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) BPHYT_RS26660
Cobalt-precorrin-6 synthase, anaerobic BPHYT_RS26670
Cobalt-precorrin-6x reductase (EC 1.3.1.54) BPHYT_RS26665
Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-) BPHYT_RS26675
Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) BPHYT_RS26675
Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) BPHYT_RS26685
Cobyric acid synthase No genes
Cobyrinic acid A,C-diamide synthase BPHYT_RS24820
Duplicated ATPase component CbrU of energizing module of predicted cobalamin ECF transporter No genes
HoxN/HupN/NixA family cobalt transporter No genes
HupE-UreJ family cobalt transporter No genes
L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) BPHYT_RS04885
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) BPHYT_RS04865
Optional hypothetical component of the B12 transporter BtuM No genes
Optional hypothetical component of the B12 transporter BtuN No genes
Outer membrane vitamin B12 receptor BtuB BPHYT_RS04850
Precorrin-6A synthase (EC 2.1.1.152) No genes
Predicted adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62) No genes
Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73) No genes
Predicted alpha-ribazole-5-phosphate synthase CblS for cobalamin biosynthesis No genes
Predicted cobalt ABC transporter periplasmic component No genes
Predicted cobalt transporter CbtA BPHYT_RS25290
  BPHYT_RS32720
Predicted cobalt transporter CbtC No genes
Predicted cobalt transporter in Bacteroides_Porphyromonas No genes
Predicted cobalt transporter in Mycobacteria No genes
Predicted cobalt transporter in Thermoplasma No genes
Predicted cobalt transporter in sulfate-reducing delta-proteobacteria No genes
Putative 2Fe-2S ferredoxin CbiW involved in B12 biosynthesis No genes
Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) BPHYT_RS04780
Sirohydrochlorin cobaltochelatase CbiK (EC 4.99.1.3) No genes
Substrate-specific component CbiM of cobalt ECF transporter No genes
Substrate-specific component CblT of predicted B12-regulated ECF transporter for dimethylbenzimidazole No genes
Substrate-specific component CbrT of predicted cobalamin ECF transporter No genes
Threonine kinase in B12 biosynthesis No genes
Transmembrane component CbiQ of energizing module of cobalt ECF transporter No genes
Transmembrane component CbrV of energizing module of predicted cobalamin ECF transporter No genes
Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) BPHYT_RS04750
  BPHYT_RS09835
  BPHYT_RS24835
Vitamin B12 ABC transporter, ATPase component BtuD No genes
Vitamin B12 ABC transporter, B12-binding component BtuF BPHYT_RS04880
Vitamin B12 ABC transporter, permease component BtuC BPHYT_RS04855

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