SEED Subsystem: Folate Biosynthesis in Bacteroides thetaiotaomicron VPI-5482

Experiments:

Role Gene Name BHIS with Trimethoprim 0.00625 mM  
⨯
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) BT0744 N.D.
  BT3216 N.D.
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) BT4258 +1.2
5-nucleotidase SurE (EC 3.1.3.5) BT4003 -2.7
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12) No genes
ATPase component of general energizing module of ECF transporters No genes
Alternative Folylglutamate Synthase No genes
Alternative dihydrofolate reductase 2 No genes
Alternative dihydrofolate reductase 3 No genes
Aminodeoxychorismate lyase (EC 4.1.3.38) BT0768 -0.6
COG0488: ATPase components of ABC transporters with duplicated ATPase domains BT1479 -0.2
Dihydrofolate reductase (EC 1.5.1.3) BT0106 +0.2
  BT2048 N.D.
Dihydrofolate synthase (EC 6.3.2.12) No genes
Dihydroneopterin aldolase (EC 4.1.2.25) BT2149 N.D.
Dihydroneopterin triphosphate epimerase No genes
Dihydroneopterin triphosphate pyrophosphohydolase No genes
Dihydroneopterin triphosphate pyrophosphohydolase type 2 No genes
Dihydropteroate synthase (EC 2.5.1.15) BT3646 N.D.
FolM Alternative dihydrofolate reductase 1 No genes
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB) No genes
Folate transporter 3 No genes
Folylpolyglutamate synthase (EC 6.3.2.17) No genes
Formate--tetrahydrofolate ligase (EC 6.3.4.3) BT0737 -3.6
GTP cyclohydrolase I (EC 3.5.4.16) type 1 BT3931 N.D.
GTP cyclohydrolase I (EC 3.5.4.16) type 2 No genes
Methionyl-tRNA formyltransferase (EC 2.1.2.9) BT3945 N.D.
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) BT1607 -4.2
Non functional Dihydropteroate synthase 2 No genes
Nucleoside triphosphate pyrophosphohydrolase MazG No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) No genes
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) BT0767 +0.1
PqqC-like protein No genes
Putative DHNTP pyrophosphatase No genes
Related to Dihydropteroate synthase No genes
Serine hydroxymethyltransferase (EC 2.1.2.1) BT0738 +0.8
Substrate-specific component FolT of folate ECF transporter No genes
Thymidine kinase (EC 2.7.1.21) BT2275 -1.2
Thymidylate synthase (EC 2.1.1.45) BT2047 N.D.
Thymidylate synthase thyX (EC 2.1.1.-) No genes
Transaldolase (EC 2.2.1.2) BT1658 -0.2
Transmembrane component of general energizing module of ECF transporters No genes
Xanthosine/inosine triphosphate pyrophosphatase No genes
alternate gene name: yzbB BT2135 -0.4

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