SEED Subsystem: Methionine Biosynthesis in Pseudomonas fluorescens FW300-N2E2

Experiments:

Role Gene Name phosphite 0.25 M  
⨯
5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) Pf6N2E2_4638 -1.5
5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Pf6N2E2_2068 -0.7
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) Pf6N2E2_5472 +0.2
Adenosylhomocysteinase (EC 3.3.1.1) Pf6N2E2_4639 N.D.
Archaeal S-adenosylmethionine synthetase (EC 2.5.1.6) No genes
Betaine--homocysteine S-methyltransferase (EC 2.1.1.5) No genes
Cystathionine beta-lyase (EC 4.4.1.8) Pf6N2E2_1491 +0.2
Cystathionine beta-lyase, type II (EC 4.4.1.8) No genes
Cystathionine beta-synthase (EC 4.2.1.22) No genes
Cystathionine gamma-lyase (EC 4.4.1.1) Pf6N2E2_5896 +0.0
Cystathionine gamma-synthase (EC 2.5.1.48) Pf6N2E2_4958 +0.1
Cysteine synthase (EC 2.5.1.47) Pf6N2E2_2700 -0.7
  Pf6N2E2_2936 +1.4
Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter No genes
Homocysteine S-methyltransferase (EC 2.1.1.10) Pf6N2E2_4283 -0.2
Homoserine O-acetyltransferase (EC 2.3.1.31) Pf6N2E2_4596 -0.3
  Pf6N2E2_4597 -0.0
Homoserine O-succinyltransferase (EC 2.3.1.46) No genes
Homoserine dehydrogenase (EC 1.1.1.3) Pf6N2E2_3143 N.D.
  Pf6N2E2_4963 +0.1
Homoserine kinase (EC 2.7.1.39) Pf6N2E2_4164 N.D.
  Pf6N2E2_6055 +0.1
Methionine ABC transporter ATP-binding protein Pf6N2E2_3927 -0.3
  Pf6N2E2_4172 -0.5
  Pf6N2E2_4912 +0.2
Methionine ABC transporter permease protein Pf6N2E2_3928 -0.0
  Pf6N2E2_4173 -1.3
Methionine ABC transporter substrate-binding protein Pf6N2E2_3926 +0.2
  Pf6N2E2_3953 +0.0
  Pf6N2E2_4174 -0.8
Methionine repressor MetJ No genes
Methionine synthase activation domain (EC 2.1.1.13) No genes
Methionine transporter MetT No genes
O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) Pf6N2E2_1768 +0.2
  Pf6N2E2_1876 -1.0
  Pf6N2E2_77 +0.1
O-succinylhomoserine sulfhydrylase (EC 2.5.1.48) Pf6N2E2_77 +0.1
Predicted regulator of methionine metabolism, ArsR family No genes
S-adenosylhomocysteine nucleosidase (EC 3.2.2.9) No genes
S-adenosylmethionine synthetase (EC 2.5.1.6) Pf6N2E2_4652 N.D.
S-ribosylhomocysteine lyase (EC 4.4.1.21) No genes
SAM-dependent methlytransferase UbiG No genes
SAM-dependent methlytransferase YrrT No genes
Serine acetyltransferase (EC 2.3.1.30) Pf6N2E2_3191 -0.2
Substrate-specific component MtsA of methionine-regulated ECF transporter No genes
Transcriptional activator MetR Pf6N2E2_5471 -0.3
Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter No genes

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