SEED Subsystem: Folate Biosynthesis in Pseudomonas fluorescens FW300-N2C3

Experiments:

Role Gene Name Carnitine Hydrochloride (N)  
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) AO356_14295 -3.4
  AO356_16065 N.D.
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) AO356_12990 -2.4
5-nucleotidase SurE (EC 3.1.3.5) No genes
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12) No genes
ATPase component of general energizing module of ECF transporters No genes
Alternative Folylglutamate Synthase No genes
Alternative dihydrofolate reductase 2 No genes
Alternative dihydrofolate reductase 3 No genes
Aminodeoxychorismate lyase (EC 4.1.3.38) AO356_20180 +0.3
COG0488: ATPase components of ABC transporters with duplicated ATPase domains AO356_02345 +0.0
Dihydrofolate reductase (EC 1.5.1.3) AO356_13235 N.D.
Dihydrofolate synthase (EC 6.3.2.12) No genes
Dihydroneopterin aldolase (EC 4.1.2.25) AO356_14290 N.D.
Dihydroneopterin triphosphate epimerase AO356_16735 +0.1
Dihydroneopterin triphosphate pyrophosphohydolase No genes
Dihydroneopterin triphosphate pyrophosphohydolase type 2 No genes
Dihydropteroate synthase (EC 2.5.1.15) AO356_07450 N.D.
FolM Alternative dihydrofolate reductase 1 AO356_16745 +0.2
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB) No genes
Folate transporter 3 No genes
Folylpolyglutamate synthase (EC 6.3.2.17) No genes
Formate--tetrahydrofolate ligase (EC 6.3.4.3) No genes
GTP cyclohydrolase I (EC 3.5.4.16) type 1 AO356_16740 -0.0
  AO356_19505 N.D.
GTP cyclohydrolase I (EC 3.5.4.16) type 2 AO356_11935 -0.0
Methionyl-tRNA formyltransferase (EC 2.1.2.9) AO356_11280 N.D.
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) AO356_01775 N.D.
  AO356_30060 -0.2
  AO356_30100 -0.1
Non functional Dihydropteroate synthase 2 No genes
Nucleoside triphosphate pyrophosphohydrolase MazG No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) AO356_20405 -0.0
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) AO356_20840 -0.2
PqqC-like protein No genes
Putative DHNTP pyrophosphatase No genes
Related to Dihydropteroate synthase No genes
Serine hydroxymethyltransferase (EC 2.1.2.1) AO356_13970 -4.4
  AO356_15725 N.D.
  AO356_16850 -0.2
Substrate-specific component FolT of folate ECF transporter No genes
Thymidine kinase (EC 2.7.1.21) No genes
Thymidylate synthase (EC 2.1.1.45) AO356_10370 N.D.
Thymidylate synthase thyX (EC 2.1.1.-) No genes
Transaldolase (EC 2.2.1.2) AO356_02175 -4.2
Transmembrane component of general energizing module of ECF transporters No genes
Xanthosine/inosine triphosphate pyrophosphatase No genes
alternate gene name: yzbB No genes

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