SEED Subsystem: Leucine Degradation and HMG-CoA Metabolism in Pseudomonas fluorescens FW300-N2E3

Role	Gene	Name	Carnitine Hydrochloride (C)
Acetoacetyl-CoA synthetase (EC 6.2.1.16)	AO353_02215		-0.1
	AO353_20355		-0.2
	AO353_21765		-0.3
Acetoacetyl-CoA synthetase [leucine] (EC 6.2.1.16)	No genes
Biotin carboxyl carrier protein of methylcrotonyl-CoA carboxylase	No genes
Biotin carboxylase of methylcrotonyl-CoA carboxylase (EC 6.3.4.14)	No genes
Branched-chain acyl-CoA dehydrogenase (EC 1.3.99.12)	No genes
Branched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit (EC 1.2.4.4)	AO353_15575		-0.0
	AO353_26635		-0.1
Branched-chain alpha-keto acid dehydrogenase, E1 component, beta subunit (EC 1.2.4.4)	AO353_15580		-0.1
	AO353_26640		-0.7
Branched-chain amino acid aminotransferase (EC 2.6.1.42)	AO353_26655		-0.1
Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex (EC 2.3.1.168)	AO353_15585		-0.2
	AO353_26645		-0.6
Dihydrolipoamide dehydrogenase (EC 1.8.1.4)	No genes
Dihydrolipoamide dehydrogenase of branched-chain alpha-keto acid dehydrogenase (EC 1.8.1.4)	AO353_26650		-0.2
Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4)	AO353_20365		N.D.
Hydroxymethylglutaryl-CoA reductase (EC 1.1.1.34)	No genes
Hydroxymethylglutaryl-CoA synthase (EC 2.3.3.10)	No genes
Isovaleryl-CoA dehydrogenase (EC 1.3.99.10)	No genes
Leucine dehydrogenase (EC 1.4.1.9)	AO353_15570		+0.1
Methylcrotonyl-CoA carboxylase biotin-containing subunit (EC 6.4.1.4)	AO353_19305		-0.2
	AO353_20335		-0.6
Methylcrotonyl-CoA carboxylase carboxyl transferase subunit (EC 6.4.1.4)	AO353_19320		-0.2
	AO353_20345		-1.2
Methylglutaconyl-CoA hydratase (EC 4.2.1.18)	AO353_20340		-0.8
Predicted transcriptional regulator of leucine degradation pathway, MerR family	No genes
Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A (EC 2.8.3.5)	AO353_27935		-2.5
Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B (EC 2.8.3.5)	AO353_27940		-2.1