SEED Subsystem: Folate Biosynthesis in Paraburkholderia bryophila 376MFSha3.1

Experiments:

Role Gene Name 2-Deoxy-D-Ribose 10 mM (C)  
⨯
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) H281DRAFT_04705 N.D.
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) H281DRAFT_05815 -3.3
5-nucleotidase SurE (EC 3.1.3.5) H281DRAFT_00840 -1.4
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12) No genes
ATPase component of general energizing module of ECF transporters No genes
Alternative Folylglutamate Synthase No genes
Alternative dihydrofolate reductase 2 No genes
Alternative dihydrofolate reductase 3 H281DRAFT_04196 +0.2
Aminodeoxychorismate lyase (EC 4.1.3.38) H281DRAFT_04702 -0.1
COG0488: ATPase components of ABC transporters with duplicated ATPase domains H281DRAFT_00263 +0.0
Dihydrofolate reductase (EC 1.5.1.3) H281DRAFT_04305 N.D.
Dihydrofolate synthase (EC 6.3.2.12) H281DRAFT_06063 N.D.
Dihydroneopterin aldolase (EC 4.1.2.25) H281DRAFT_01306 -0.1
  H281DRAFT_05823 N.D.
Dihydroneopterin triphosphate epimerase No genes
Dihydroneopterin triphosphate pyrophosphohydolase No genes
Dihydroneopterin triphosphate pyrophosphohydolase type 2 H281DRAFT_04621 +0.3
Dihydropteroate synthase (EC 2.5.1.15) H281DRAFT_04409 N.D.
FolM Alternative dihydrofolate reductase 1 H281DRAFT_05822 -0.5
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB) No genes
Folate transporter 3 No genes
Folylpolyglutamate synthase (EC 6.3.2.17) H281DRAFT_06063 N.D.
Formate--tetrahydrofolate ligase (EC 6.3.4.3) No genes
GTP cyclohydrolase I (EC 3.5.4.16) type 1 H281DRAFT_01599 +1.0
GTP cyclohydrolase I (EC 3.5.4.16) type 2 H281DRAFT_06014 +0.0
Methionyl-tRNA formyltransferase (EC 2.1.2.9) H281DRAFT_02240 N.D.
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) H281DRAFT_00463 N.D.
Non functional Dihydropteroate synthase 2 No genes
Nucleoside triphosphate pyrophosphohydrolase MazG No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) H281DRAFT_03954 -1.4
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) H281DRAFT_04702 -0.1
PqqC-like protein No genes
Putative DHNTP pyrophosphatase No genes
Related to Dihydropteroate synthase H281DRAFT_01309 -0.2
Serine hydroxymethyltransferase (EC 2.1.2.1) H281DRAFT_00990 N.D.
  H281DRAFT_02468 +0.2
  H281DRAFT_04726 N.D.
Substrate-specific component FolT of folate ECF transporter No genes
Thymidine kinase (EC 2.7.1.21) No genes
Thymidylate synthase (EC 2.1.1.45) H281DRAFT_04307 N.D.
Thymidylate synthase thyX (EC 2.1.1.-) No genes
Transaldolase (EC 2.2.1.2) H281DRAFT_00286 -0.8
Transmembrane component of general energizing module of ECF transporters No genes
Xanthosine/inosine triphosphate pyrophosphatase No genes
alternate gene name: yzbB No genes

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