SEED Subsystem: Folate Biosynthesis in Sphingomonas koreensis DSMZ 15582

Experiments:

Role Gene Name Phosphomycin 0.005 mg/ml  
⨯
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) Ga0059261_1977 N.D.
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) Ga0059261_0735 -0.1
5-nucleotidase SurE (EC 3.1.3.5) Ga0059261_0278 +0.0
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12) No genes
ATPase component of general energizing module of ECF transporters No genes
Alternative Folylglutamate Synthase No genes
Alternative dihydrofolate reductase 2 No genes
Alternative dihydrofolate reductase 3 No genes
Aminodeoxychorismate lyase (EC 4.1.3.38) Ga0059261_2227 +0.1
COG0488: ATPase components of ABC transporters with duplicated ATPase domains No genes
Dihydrofolate reductase (EC 1.5.1.3) Ga0059261_1491 +0.0
  Ga0059261_1835 -0.1
  Ga0059261_2692 N.D.
Dihydrofolate synthase (EC 6.3.2.12) No genes
Dihydroneopterin aldolase (EC 4.1.2.25) Ga0059261_1515 N.D.
  Ga0059261_3613 +0.1
Dihydroneopterin triphosphate epimerase No genes
Dihydroneopterin triphosphate pyrophosphohydolase No genes
Dihydroneopterin triphosphate pyrophosphohydolase type 2 No genes
Dihydropteroate synthase (EC 2.5.1.15) Ga0059261_1965 N.D.
FolM Alternative dihydrofolate reductase 1 Ga0059261_3612 +0.2
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB) No genes
Folate transporter 3 No genes
Folylpolyglutamate synthase (EC 6.3.2.17) No genes
Formate--tetrahydrofolate ligase (EC 6.3.4.3) No genes
GTP cyclohydrolase I (EC 3.5.4.16) type 1 Ga0059261_3611 N.D.
GTP cyclohydrolase I (EC 3.5.4.16) type 2 No genes
Methionyl-tRNA formyltransferase (EC 2.1.2.9) Ga0059261_0646 N.D.
  Ga0059261_4088 -0.0
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) Ga0059261_2527 N.D.
Non functional Dihydropteroate synthase 2 No genes
Nucleoside triphosphate pyrophosphohydrolase MazG No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) No genes
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) Ga0059261_2227 +0.1
PqqC-like protein No genes
Putative DHNTP pyrophosphatase No genes
Related to Dihydropteroate synthase No genes
Serine hydroxymethyltransferase (EC 2.1.2.1) Ga0059261_1986 +0.2
Substrate-specific component FolT of folate ECF transporter No genes
Thymidine kinase (EC 2.7.1.21) Ga0059261_2144 +0.0
Thymidylate synthase (EC 2.1.1.45) Ga0059261_2693 N.D.
Thymidylate synthase thyX (EC 2.1.1.-) No genes
Transaldolase (EC 2.2.1.2) Ga0059261_1419 +0.5
Transmembrane component of general energizing module of ECF transporters No genes
Xanthosine/inosine triphosphate pyrophosphatase No genes
alternate gene name: yzbB Ga0059261_0952 -3.4

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