SEED Subsystem: NAD and NADP cofactor biosynthesis global in Mycobacterium tuberculosis H37Rv

Experiments:

Role Gene Name 7H9 with Isoniazid 0.025 ug/mL  
3-hydroxyanthranilate 3,4-dioxygenase (EC 1.13.11.6) No genes
ADP-ribose pyrophosphatase (EC 3.6.1.13) Rv1700 N.D.
Amidases related to nicotinamidase No genes
C-terminal domain of CinA type S Rv1901 -1.4
C-terminal domain of CinA type S homolog No genes
Glutamine amidotransferase chain of NAD synthetase Rv2438c N.D.
Indoleamine 2,3-dioxygenase (EC 1.13.11.52) No genes
Isochorismatase (EC 3.3.2.1) of siderophore biosynthesis No genes
Kynureninase (EC 3.7.1.3) No genes
Kynurenine 3-monooxygenase (EC 1.14.13.9) No genes
Kynurenine formamidase (EC 3.5.1.9) No genes
Kynurenine formamidase, bacterial (EC 3.5.1.9) Rv1716 +0.2
Kynurenine formamidase, yeast-type BNA7 (EC 3.5.1.9) No genes
L-Aspartate dehydrogenase (EC 1.4.1.21) No genes
L-aspartate oxidase (EC 1.4.3.16) Rv1595 N.D.
N-Ribosylnicotinamide phosphorylase (EC 2.4.2.1) No genes
NAD kinase (EC 2.7.1.23) Rv1695 N.D.
NAD pyrophosphatase, periplasmic (EC 3.6.1.22) No genes
NAD synthetase (EC 6.3.1.5) Rv2438c N.D.
NAD transporter of endosymbionts, possible No genes
NMN 5'-nucleotidase, extracellular (EC 3.1.3.5) No genes
NMN phosphatase (EC 3.1.3.5) No genes
NMN synthetase (EC 6.3.1.-) No genes
NadR transcriptional regulator No genes
Niacin transporter NiaP No genes
Niacin transporter in yeast, DAL5 family No genes
Nicotinamidase (EC 3.5.1.19) Rv2043c -0.6
  Rv2044c -0.3
Nicotinamidase family protein YcaC No genes
Nicotinamidase/isochorismatase family protein No genes
Nicotinamide phosphoribosyltransferase (EC 2.4.2.12) No genes
Nicotinamide-nucleotide adenylyltransferase (EC 2.7.7.1) No genes
Nicotinamide-nucleotide adenylyltransferase (EC 2.7.7.1), eukaryotic PNAT family No genes
Nicotinamide-nucleotide adenylyltransferase, NadM family (EC 2.7.7.1) No genes
Nicotinamide-nucleotide adenylyltransferase, NadR family (EC 2.7.7.1) Rv0212c -0.0
Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Rv0573c +0.2
  Rv1330c -0.2
Nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18) Rv2421c N.D.
Nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18), eukaryotic PNAT family No genes
Nicotinate-nucleotide adenylyltransferase, NadM family (EC 2.7.7.18) No genes
Nicotine adenine dinucleotide glycohydrolase (NADGH) (EC 3.2.2.5) No genes
Nudix-related transcriptional regulator NrtR Rv1593c -0.9
Predicted N-ribosylNicotinamide CRP-like regulator No genes
Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19) Rv1596 N.D.
Quinolinate synthetase (EC 2.5.1.72) Rv1594 N.D.
Ribosyl nicotinamide transporter, PnuC-like No genes
Ribosylnicotinamide kinase (EC 2.7.1.22) Rv0212c -0.0
Ribosylnicotinamide kinase, eukaryotic (EC 2.7.1.22) No genes
Substrate-specific component NiaX of predicted niacin ECF transporter No genes
Transcriptional repressor for NAD biosynthesis in gram-positives No genes
Tryptophan 2,3-dioxygenase (EC 1.13.11.11) No genes

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