SEED Subsystem: DNA-replication in Mycobacterium tuberculosis H37Rv

Experiments:

Role Gene Name 7H9 with Moxifloxacin 0.121 ug/mL  
⨯
ATP-dependent DNA helicase RecG (EC 3.6.1.-) Rv2973c -0.3
ATP-dependent DNA helicase RecQ No genes
Arrested fork binding No genes
Chromosomal replication initiator protein DnaA Rv0001 N.D.
Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4) Rv2594c N.D.
DNA polymerase I (EC 2.7.7.7) Rv1629 N.D.
  Rv2090 -0.0
DNA polymerase II (EC 2.7.7.7) No genes
DNA polymerase III alpha subunit (EC 2.7.7.7) Rv1547 N.D.
  Rv3370c +0.1
DNA polymerase III beta subunit (EC 2.7.7.7) Rv0002 N.D.
DNA polymerase III chi subunit (EC 2.7.7.7) No genes
DNA polymerase III delta prime subunit (EC 2.7.7.7) Rv3644c N.D.
DNA polymerase III delta subunit (EC 2.7.7.7) Rv2413c N.D.
DNA polymerase III epsilon subunit (EC 2.7.7.7) Rv3711c -0.0
DNA polymerase III psi subunit (EC 2.7.7.7) No genes
DNA polymerase III subunits gamma and tau (EC 2.7.7.7) Rv3721c N.D.
DNA polymerase III theta subunit (EC 2.7.7.7) No genes
DNA primase (EC 2.7.7.-) Rv2343c N.D.
DNA primase (EC 2.7.7.-), phage-associated No genes
DNA primase TraC (EC 2.7.7.-) No genes
DNA repair protein RecN Rv1696 -0.1
DNA replication protein DnaC No genes
DNA replication terminus site-binding protein No genes
Exodeoxyribonuclease V alpha chain (EC 3.1.11.5) No genes
Exodeoxyribonuclease V beta chain (EC 3.1.11.5) Rv0630c +0.5
Exodeoxyribonuclease V gamma chain (EC 3.1.11.5) Rv0631c +0.4
Helicase PriA essential for oriC/DnaA-independent DNA replication Rv1402 N.D.
Helicase loader DnaI No genes
Holliday junction DNA helicase RuvA Rv2593c N.D.
Holliday junction DNA helicase RuvB Rv2592c N.D.
Primosomal protein I No genes
Primosomal replication protein N No genes
Primosomal replication protein N prime prime No genes
RecA protein No genes
Recombination protein RecR Rv3715c -0.1
Replicative DNA helicase (EC 3.6.1.-) No genes
Replicative DNA helicase (EC 3.6.1.-) [SA14-24] No genes
Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) No genes
Transcription-repair coupling factor Rv1020 -1.1

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