SEED Subsystem: Folate Biosynthesis in Synechocystis sp000284455 PCC 6803

Experiments:

Role Gene Name nitrite (N)  
⨯
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) SGL_RS02755 N.D.
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) SGL_RS04360 -2.3
5-nucleotidase SurE (EC 3.1.3.5) SGL_RS06530 -0.1
  SGL_RS18120 +1.3
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12) No genes
ATPase component of general energizing module of ECF transporters No genes
Alternative Folylglutamate Synthase No genes
Alternative dihydrofolate reductase 2 No genes
Alternative dihydrofolate reductase 3 No genes
Aminodeoxychorismate lyase (EC 4.1.3.38) SGL_RS07250 -2.2
COG0488: ATPase components of ABC transporters with duplicated ATPase domains SGL_RS11385 -0.5
Dihydrofolate reductase (EC 1.5.1.3) SGL_RS00345 -0.4
Dihydrofolate synthase (EC 6.3.2.12) No genes
Dihydroneopterin aldolase (EC 4.1.2.25) SGL_RS11510 -4.3
Dihydroneopterin triphosphate epimerase No genes
Dihydroneopterin triphosphate pyrophosphohydolase SGL_RS11505 N.D.
Dihydroneopterin triphosphate pyrophosphohydolase type 2 No genes
Dihydropteroate synthase (EC 2.5.1.15) SGL_RS05470 -2.4
FolM Alternative dihydrofolate reductase 1 SGL_RS07840 -3.0
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB) No genes
Folate transporter 3 SGL_RS14315 +1.8
Folylpolyglutamate synthase (EC 6.3.2.17) No genes
Formate--tetrahydrofolate ligase (EC 6.3.4.3) No genes
GTP cyclohydrolase I (EC 3.5.4.16) type 1 SGL_RS14545 N.D.
GTP cyclohydrolase I (EC 3.5.4.16) type 2 No genes
Methionyl-tRNA formyltransferase (EC 2.1.2.9) SGL_RS13995 N.D.
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) SGL_RS13155 N.D.
Non functional Dihydropteroate synthase 2 No genes
Nucleoside triphosphate pyrophosphohydrolase MazG No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) No genes
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) SGL_RS10370 -4.9
PqqC-like protein No genes
Putative DHNTP pyrophosphatase No genes
Related to Dihydropteroate synthase No genes
Serine hydroxymethyltransferase (EC 2.1.2.1) SGL_RS04690 N.D.
Substrate-specific component FolT of folate ECF transporter No genes
Thymidine kinase (EC 2.7.1.21) No genes
Thymidylate synthase (EC 2.1.1.45) No genes
Thymidylate synthase thyX (EC 2.1.1.-) SGL_RS04435 N.D.
Transaldolase (EC 2.2.1.2) SGL_RS03080 +0.0
Transmembrane component of general energizing module of ECF transporters No genes
Xanthosine/inosine triphosphate pyrophosphatase SGL_RS12040 -0.2
alternate gene name: yzbB No genes

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