SEED Subsystem: Serine-glyoxylate cycle in Cupriavidus basilensis FW507-4G11

Experiments:

Role Gene Name L-Tryptophan (N)  
⨯
3-ketoacyl-CoA thiolase (EC 2.3.1.16) RR42_RS00885 -0.0
  RR42_RS11085 -0.1
  RR42_RS16595 +0.1
  RR42_RS22625 +0.1
  RR42_RS37020 -0.1
5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) RR42_RS01385 -7.0
5-FCL-like protein, but predicted not to be 5-formyltetrahydrofolate cyclo-ligase (5-FCL) No genes
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) RR42_RS01400 -1.4
Acetoacetyl-CoA reductase (EC 1.1.1.36) RR42_RS07615 -1.4
  RR42_RS26085 +0.8
Acetyl-CoA acetyltransferase (EC 2.3.1.9) RR42_RS24970 +0.3
  RR42_RS28055 -0.0
Aconitate hydratase (EC 4.2.1.3) No genes
Citrate synthase (EC 2.3.3.1) No genes
Citrate synthase (si) (EC 2.3.3.1) RR42_RS09325 -0.1
  RR42_RS10505 -0.4
  RR42_RS14430 N.D.
  RR42_RS32385 -0.2
  RR42_RS36245 +0.3
Enolase (EC 4.2.1.11) RR42_RS06175 N.D.
  RR42_RS33730 +0.1
Formate--tetrahydrofolate ligase (EC 6.3.4.3) No genes
Formiminotetrahydrofolate cyclodeaminase (EC 4.3.1.4) No genes
Fumarate hydratase class I, aerobic (EC 4.2.1.2) RR42_RS13905 -0.0
  RR42_RS27740 -0.1
Fumarate hydratase class I, anaerobic (EC 4.2.1.2) No genes
GDSL-like lipase/acylhydrolase No genes
Glycerate kinase (EC 2.7.1.31) RR42_RS23230 +0.6
Isocitrate lyase (EC 4.1.3.1) RR42_RS12200 -0.1
  RR42_RS22175 -0.2
  RR42_RS25845 +0.1
Malate dehydrogenase (EC 1.1.1.37) RR42_RS02230 +0.2
  RR42_RS14465 N.D.
  RR42_RS29130 -0.2
Malate synthase-related protein No genes
Malyl-CoA lyase (EC 4.1.3.24) RR42_RS24325 +0.0
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) RR42_RS07345 N.D.
Methylcrotonyl-CoA carboxylase biotin-containing subunit (EC 6.4.1.4) RR42_RS26895 -0.4
  RR42_RS29420 +0.3
  RR42_RS32735 +0.1
Methylcrotonyl-CoA carboxylase carboxyl transferase subunit (EC 6.4.1.4) RR42_RS26905 -0.9
  RR42_RS29410 -0.2
Methylene tetrahydromethanopterin dehydrogenase (EC 1.5.99.9) No genes
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) RR42_RS07345 N.D.
Methylmalonyl-CoA mutase (EC 5.4.99.2) RR42_RS01600 +0.3
N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase (EC 3.5.4.27) No genes
Phosphoenolpyruvate carboxykinase [ATP] (EC 4.1.1.49) No genes
Phosphoglyceromutase No genes
Propionyl-CoA carboxylase beta chain (EC 6.4.1.3) RR42_RS01335 -0.2
Propionyl-CoA carboxylase carboxyl transferase subunit (EC 6.4.1.3) No genes
Putative malate dehydrogenase (EC 1.1.1.37), similar to archaeal MJ1425 No genes
Serine hydroxymethyltransferase (EC 2.1.2.1) RR42_RS15485 N.D.
Serine--glyoxylate aminotransferase (EC 2.6.1.45) RR42_RS30400 +0.1
Serine--pyruvate aminotransferase (EC 2.6.1.51) No genes
Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase No genes
Succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) RR42_RS02185 -0.0
  RR42_RS14445 N.D.
Succinate dehydrogenase iron-sulfur protein (EC 1.3.99.1) RR42_RS02215 +0.0
  RR42_RS14440 N.D.
Succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5) RR42_RS03100 N.D.
  RR42_RS31380 -0.2
Succinyl-CoA ligase [ADP-forming] beta chain (EC 6.2.1.5) RR42_RS03095 -2.3
  RR42_RS31375 -0.1
Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A (EC 2.8.3.5) RR42_RS06555 +0.1
Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B (EC 2.8.3.5) RR42_RS06560 N.D.
crotonyl-CoA reductase No genes
cytosolic long-chain acyl-CoA thioester hydrolase family protein RR42_RS29520 +0.0
decarboxylase No genes
isobutyryl-CoA dehydrogenase RR42_RS24375 +0.1
low-specificity D-threonine aldolase RR42_RS28440 +0.2
  RR42_RS28855 -0.1
  RR42_RS33450 +0.3
polyhydroxyalkanoate synthesis repressor PhaR No genes
putative glycerate kinase No genes
putative isobutyryl-CoA mutase, chain B No genes

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