SEED Subsystem: Folate Biosynthesis in Cupriavidus basilensis FW507-4G11

Experiments:

Role Gene Name L-Tryptophan (N)  
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) RR42_RS17240 N.D.
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) RR42_RS01400 -1.4
5-nucleotidase SurE (EC 3.1.3.5) RR42_RS13200 -0.2
  RR42_RS32020 -0.0
  RR42_RS32200 N.D.
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12) No genes
ATPase component of general energizing module of ECF transporters No genes
Alternative Folylglutamate Synthase No genes
Alternative dihydrofolate reductase 2 No genes
Alternative dihydrofolate reductase 3 RR42_RS03160 +0.1
Aminodeoxychorismate lyase (EC 4.1.3.38) RR42_RS16495 +0.6
  RR42_RS17265 -0.0
COG0488: ATPase components of ABC transporters with duplicated ATPase domains RR42_RS14685 -0.0
Dihydrofolate reductase (EC 1.5.1.3) RR42_RS14745 N.D.
Dihydrofolate synthase (EC 6.3.2.12) No genes
Dihydroneopterin aldolase (EC 4.1.2.25) RR42_RS01440 N.D.
Dihydroneopterin triphosphate epimerase No genes
Dihydroneopterin triphosphate pyrophosphohydolase No genes
Dihydroneopterin triphosphate pyrophosphohydolase type 2 RR42_RS02470 +0.5
Dihydropteroate synthase (EC 2.5.1.15) RR42_RS13480 N.D.
FolM Alternative dihydrofolate reductase 1 RR42_RS01435 +0.0
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB) No genes
Folate transporter 3 No genes
Folylpolyglutamate synthase (EC 6.3.2.17) No genes
Formate--tetrahydrofolate ligase (EC 6.3.4.3) No genes
GTP cyclohydrolase I (EC 3.5.4.16) type 1 RR42_RS34345 +0.3
GTP cyclohydrolase I (EC 3.5.4.16) type 2 RR42_RS15000 +0.1
Methionyl-tRNA formyltransferase (EC 2.1.2.9) RR42_RS20465 N.D.
  RR42_RS23345 -0.1
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) RR42_RS07345 N.D.
Non functional Dihydropteroate synthase 2 No genes
Nucleoside triphosphate pyrophosphohydrolase MazG No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) No genes
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) RR42_RS17265 -0.0
PqqC-like protein No genes
Putative DHNTP pyrophosphatase No genes
Related to Dihydropteroate synthase No genes
Serine hydroxymethyltransferase (EC 2.1.2.1) RR42_RS15485 N.D.
Substrate-specific component FolT of folate ECF transporter No genes
Thymidine kinase (EC 2.7.1.21) No genes
Thymidylate synthase (EC 2.1.1.45) RR42_RS14740 N.D.
Thymidylate synthase thyX (EC 2.1.1.-) No genes
Transaldolase (EC 2.2.1.2) RR42_RS13050 -1.1
Transmembrane component of general energizing module of ECF transporters No genes
Xanthosine/inosine triphosphate pyrophosphatase No genes
alternate gene name: yzbB RR42_RS11610 -0.0

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