SEED Subsystem: Valine degradation in Cupriavidus basilensis FW507-4G11

Experiments:

Role Gene Name L-Valine (N)  
⨯
3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35) RR42_RS02510 +0.1
  RR42_RS05760 +0.1
  RR42_RS10265 +0.2
  RR42_RS11095 -0.1
  RR42_RS22630 -0.1
  RR42_RS28325 +0.1
  RR42_RS29465 +0.0
  RR42_RS31050 +0.2
  RR42_RS35270 -0.1
3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) RR42_RS24030 +0.0
  RR42_RS25325 -0.2
  RR42_RS25640 -0.1
  RR42_RS28555 N.D.
3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) RR42_RS28545 -2.0
Branched-chain acyl-CoA dehydrogenase (EC 1.3.99.12) No genes
Branched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit (EC 1.2.4.4) RR42_RS21785 +0.0
  RR42_RS33045 -0.1
Branched-chain alpha-keto acid dehydrogenase, E1 component, beta subunit (EC 1.2.4.4) RR42_RS21785 +0.0
  RR42_RS33050 +0.0
Branched-chain amino acid aminotransferase (EC 2.6.1.42) RR42_RS25890 -0.2
Butyrate kinase (EC 2.7.2.7) No genes
Butyryl-CoA dehydrogenase (EC 1.3.99.2) RR42_RS11345 +0.2
  RR42_RS13540 -0.3
  RR42_RS16575 +0.3
  RR42_RS16795 -0.0
  RR42_RS21420 +0.1
  RR42_RS23155 -0.0
  RR42_RS24795 +0.1
  RR42_RS24965 -0.2
  RR42_RS25105 -0.4
  RR42_RS25970 -0.2
  RR42_RS28565 -0.9
  RR42_RS28610 +0.3
  RR42_RS29500 +0.1
  RR42_RS31105 +0.0
  RR42_RS31905 +0.3
  RR42_RS31910 -0.5
  RR42_RS31925 N.D.
  RR42_RS31930 -0.4
  RR42_RS36460 -0.2
  RR42_RS36490 +0.2
Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex (EC 2.3.1.168) RR42_RS33055 +0.1
Dihydrolipoamide dehydrogenase of branched-chain alpha-keto acid dehydrogenase (EC 1.8.1.4) No genes
Enoyl-CoA hydratase (EC 4.2.1.17) RR42_RS00730 -0.0
  RR42_RS02510 +0.1
  RR42_RS02525 +0.1
  RR42_RS03015 +0.2
  RR42_RS04550 +0.1
  RR42_RS05755 +0.3
  RR42_RS10250 -0.4
  RR42_RS10265 +0.2
  RR42_RS10270 -0.7
  RR42_RS11095 -0.1
  RR42_RS12500 +0.0
  RR42_RS12795 +0.1
  RR42_RS13545 N.D.
  RR42_RS16175 +0.4
  RR42_RS16790 +0.2
  RR42_RS18250 -0.1
  RR42_RS19805 -0.6
  RR42_RS22630 -0.1
  RR42_RS22680 +0.2
  RR42_RS23295 +0.1
  RR42_RS23450 +0.1
  RR42_RS23710 -0.4
  RR42_RS24355 -0.1
  RR42_RS24895 -0.4
  RR42_RS25480 -0.2
  RR42_RS25525 -0.1
  RR42_RS25900 +0.0
  RR42_RS28050 N.D.
  RR42_RS28325 +0.1
  RR42_RS28330 -0.5
  RR42_RS29425 +0.6
  RR42_RS29465 +0.0
  RR42_RS29940 -0.1
  RR42_RS29945 -0.3
  RR42_RS31580 +0.1
  RR42_RS31935 +0.3
  RR42_RS31945 -0.1
  RR42_RS34175 +0.4
  RR42_RS34180 -0.1
  RR42_RS34905 -0.8
  RR42_RS35270 -0.1
  RR42_RS36495 +0.2
Enoyl-CoA hydratase [valine degradation] (EC 4.2.1.17) RR42_RS36335 +0.1
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex (EC 2.3.1.-) No genes
Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27) RR42_RS01580 -0.0
  RR42_RS24025 N.D.
  RR42_RS25315 +0.0
  RR42_RS25635 N.D.
  RR42_RS28560 -1.3
  RR42_RS34225 -0.2
Predicted transcriptional regulator of leucine degradation pathway, MerR family No genes
Probable acyl-CoA dehydrogenase (EC 1.3.99.3) RR42_RS24990 -0.0
  RR42_RS36595 -0.2
Transcriptional regulator BkdR of isoleucine and valine catabolism operon RR42_RS02930 +0.6
phosphotransbutyrylase (EC 2.3.1.19) No genes

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