SEED Subsystem: Methionine Biosynthesis in Rhodospirillum rubrum S1H

Experiments:

Role Gene Name carbon source anaerobic Succinic Acid 31.25 mM  
⨯
5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) Rru_A1530 -2.9
5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Rru_A1531 N.D.
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) Rru_A1718 +0.0
Adenosylhomocysteinase (EC 3.3.1.1) Rru_A3444 N.D.
Archaeal S-adenosylmethionine synthetase (EC 2.5.1.6) No genes
Betaine--homocysteine S-methyltransferase (EC 2.1.1.5) No genes
Cystathionine beta-lyase (EC 4.4.1.8) Rru_A1613 -1.9
Cystathionine beta-lyase, type II (EC 4.4.1.8) No genes
Cystathionine beta-synthase (EC 4.2.1.22) Rru_A0787 +0.4
Cystathionine gamma-lyase (EC 4.4.1.1) Rru_A0786 +0.1
Cystathionine gamma-synthase (EC 2.5.1.48) No genes
Cysteine synthase (EC 2.5.1.47) Rru_A1616 +0.7
  Rru_A3794 N.D.
Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter No genes
Homocysteine S-methyltransferase (EC 2.1.1.10) No genes
Homoserine O-acetyltransferase (EC 2.3.1.31) Rru_A3266 -2.2
  Rru_A3267 -3.3
Homoserine O-succinyltransferase (EC 2.3.1.46) No genes
Homoserine dehydrogenase (EC 1.1.1.3) Rru_A2410 -0.7
Homoserine kinase (EC 2.7.1.39) Rru_A3053 N.D.
Methionine ABC transporter ATP-binding protein Rru_A0407 N.D.
  Rru_A0788 -0.4
  Rru_A2419 -0.1
  Rru_A2909 N.D.
  Rru_A3223 +0.7
Methionine ABC transporter permease protein Rru_A0789 N.D.
  Rru_A2418 -0.5
Methionine ABC transporter substrate-binding protein Rru_A0778 +0.2
  Rru_A0791 -0.4
  Rru_A2417 +0.2
Methionine repressor MetJ No genes
Methionine synthase activation domain (EC 2.1.1.13) No genes
Methionine transporter MetT No genes
O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) Rru_A0774 -0.2
  Rru_A0784 -0.0
  Rru_A1836 -0.5
  Rru_A2075 -0.5
  Rru_A3214 -2.4
O-succinylhomoserine sulfhydrylase (EC 2.5.1.48) Rru_A0774 -0.2
  Rru_A0784 -0.0
  Rru_A1836 -0.5
  Rru_A2075 -0.5
Predicted regulator of methionine metabolism, ArsR family No genes
S-adenosylhomocysteine nucleosidase (EC 3.2.2.9) No genes
S-adenosylmethionine synthetase (EC 2.5.1.6) Rru_A0917 -0.5
  Rru_A3776 N.D.
S-ribosylhomocysteine lyase (EC 4.4.1.21) No genes
SAM-dependent methlytransferase UbiG No genes
SAM-dependent methlytransferase YrrT No genes
Serine acetyltransferase (EC 2.3.1.30) Rru_A0792 -0.9
  Rru_A2029 -1.0
Substrate-specific component MtsA of methionine-regulated ECF transporter No genes
Transcriptional activator MetR No genes
Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter No genes

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