SEED Subsystem: Leucine Degradation and HMG-CoA Metabolism in Pseudomonas fluorescens FW300-N2E2

Experiments:

Role Gene Name L-Isoleucine (C)  
⨯
Acetoacetyl-CoA synthetase (EC 6.2.1.16) Pf6N2E2_2042 -0.2
  Pf6N2E2_2190 +0.2
  Pf6N2E2_5827 -0.1
Acetoacetyl-CoA synthetase [leucine] (EC 6.2.1.16) No genes
Biotin carboxyl carrier protein of methylcrotonyl-CoA carboxylase No genes
Biotin carboxylase of methylcrotonyl-CoA carboxylase (EC 6.3.4.14) No genes
Branched-chain acyl-CoA dehydrogenase (EC 1.3.99.12) No genes
Branched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit (EC 1.2.4.4) Pf6N2E2_481 -5.1
Branched-chain alpha-keto acid dehydrogenase, E1 component, beta subunit (EC 1.2.4.4) Pf6N2E2_480 -4.6
Branched-chain amino acid aminotransferase (EC 2.6.1.42) Pf6N2E2_477 -5.5
Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex (EC 2.3.1.168) Pf6N2E2_479 -5.6
Dihydrolipoamide dehydrogenase (EC 1.8.1.4) Pf6N2E2_4251 -0.1
Dihydrolipoamide dehydrogenase of branched-chain alpha-keto acid dehydrogenase (EC 1.8.1.4) Pf6N2E2_478 -3.6
Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) Pf6N2E2_1040 +0.7
  Pf6N2E2_1041 +0.2
  Pf6N2E2_2189 -0.6
Hydroxymethylglutaryl-CoA reductase (EC 1.1.1.34) No genes
Hydroxymethylglutaryl-CoA synthase (EC 2.3.3.10) Pf6N2E2_1837 +0.2
Isovaleryl-CoA dehydrogenase (EC 1.3.99.10) No genes
Leucine dehydrogenase (EC 1.4.1.9) Pf6N2E2_5294 +0.1
Methylcrotonyl-CoA carboxylase biotin-containing subunit (EC 6.4.1.4) Pf6N2E2_2194 -0.2
  Pf6N2E2_2411 -0.2
Methylcrotonyl-CoA carboxylase carboxyl transferase subunit (EC 6.4.1.4) Pf6N2E2_2192 -0.2
  Pf6N2E2_2409 -0.0
Methylglutaconyl-CoA hydratase (EC 4.2.1.18) Pf6N2E2_2193 -0.4
Predicted transcriptional regulator of leucine degradation pathway, MerR family No genes
Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A (EC 2.8.3.5) Pf6N2E2_2111 -0.2
Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B (EC 2.8.3.5) Pf6N2E2_2112 +0.0

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