SEED Subsystem: Methionine Biosynthesis in Pseudomonas fluorescens FW300-N2E3

Experiments:

Role Gene Name Thallium(I) acetate 0.008 mg/ml  
⨯
5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) AO353_08015 +0.0
5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) AO353_21615 +0.2
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) AO353_16215 -0.0
Adenosylhomocysteinase (EC 3.3.1.1) AO353_08010 N.D.
Archaeal S-adenosylmethionine synthetase (EC 2.5.1.6) No genes
Betaine--homocysteine S-methyltransferase (EC 2.1.1.5) No genes
Cystathionine beta-lyase (EC 4.4.1.8) AO353_24330 -0.0
Cystathionine beta-lyase, type II (EC 4.4.1.8) No genes
Cystathionine beta-synthase (EC 4.2.1.22) AO353_23290 +0.6
Cystathionine gamma-lyase (EC 4.4.1.1) AO353_23295 -0.0
Cystathionine gamma-synthase (EC 2.5.1.48) No genes
Cysteine synthase (EC 2.5.1.47) AO353_17060 +0.1
  AO353_18020 -0.5
Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter No genes
Homocysteine S-methyltransferase (EC 2.1.1.10) AO353_10010 +0.2
Homoserine O-acetyltransferase (EC 2.3.1.31) AO353_08180 +0.1
  AO353_08185 +0.2
Homoserine O-succinyltransferase (EC 2.3.1.46) No genes
Homoserine dehydrogenase (EC 1.1.1.3) AO353_04355 -1.2
Homoserine kinase (EC 2.7.1.39) AO353_00930 +0.2
  AO353_10920 N.D.
Methionine ABC transporter ATP-binding protein AO353_06750 +0.2
  AO353_10890 -0.9
  AO353_11635 -0.2
  AO353_19905 +0.0
  AO353_22190 -0.2
Methionine ABC transporter permease protein AO353_10885 -1.7
  AO353_11630 +0.2
  AO353_22195 +0.4
Methionine ABC transporter substrate-binding protein AO353_10880 -0.6
  AO353_11595 +0.0
  AO353_11640 -0.0
  AO353_22185 +0.2
Methionine repressor MetJ No genes
Methionine synthase activation domain (EC 2.1.1.13) No genes
Methionine transporter MetT No genes
O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) AO353_20695 +0.5
O-succinylhomoserine sulfhydrylase (EC 2.5.1.48) AO353_20695 +0.5
Predicted regulator of methionine metabolism, ArsR family No genes
S-adenosylhomocysteine nucleosidase (EC 3.2.2.9) No genes
S-adenosylmethionine synthetase (EC 2.5.1.6) AO353_07965 N.D.
S-ribosylhomocysteine lyase (EC 4.4.1.21) No genes
SAM-dependent methlytransferase UbiG No genes
SAM-dependent methlytransferase YrrT No genes
Serine acetyltransferase (EC 2.3.1.30) AO353_11685 -0.3
  AO353_11975 +0.0
  AO353_15825 +0.1
  AO353_21195 +0.1
Substrate-specific component MtsA of methionine-regulated ECF transporter No genes
Transcriptional activator MetR AO353_16210 +0.2
Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter No genes

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