SEED Subsystem: Folate Biosynthesis in Pseudomonas fluorescens FW300-N2E3

Experiments:

Role Gene Name Cobalt chloride 0.32 mM  
⨯
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) AO353_07355 -2.9
  AO353_14390 N.D.
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) AO353_08780 -0.1
5-nucleotidase SurE (EC 3.1.3.5) No genes
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12) No genes
ATPase component of general energizing module of ECF transporters No genes
Alternative Folylglutamate Synthase No genes
Alternative dihydrofolate reductase 2 No genes
Alternative dihydrofolate reductase 3 No genes
Aminodeoxychorismate lyase (EC 4.1.3.38) AO353_01350 -0.4
COG0488: ATPase components of ABC transporters with duplicated ATPase domains AO353_00525 -0.5
Dihydrofolate reductase (EC 1.5.1.3) AO353_08370 N.D.
  AO353_28310 +0.2
Dihydrofolate synthase (EC 6.3.2.12) No genes
Dihydroneopterin aldolase (EC 4.1.2.25) AO353_07360 N.D.
Dihydroneopterin triphosphate epimerase AO353_04965 +1.4
Dihydroneopterin triphosphate pyrophosphohydolase No genes
Dihydroneopterin triphosphate pyrophosphohydolase type 2 No genes
Dihydropteroate synthase (EC 2.5.1.15) AO353_05600 N.D.
FolM Alternative dihydrofolate reductase 1 AO353_04955 +1.6
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB) No genes
Folate transporter 3 No genes
Folylpolyglutamate synthase (EC 6.3.2.17) No genes
Formate--tetrahydrofolate ligase (EC 6.3.4.3) No genes
GTP cyclohydrolase I (EC 3.5.4.16) type 1 AO353_02285 N.D.
  AO353_04960 +0.5
GTP cyclohydrolase I (EC 3.5.4.16) type 2 AO353_10125 -0.0
Methionyl-tRNA formyltransferase (EC 2.1.2.9) AO353_10635 N.D.
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) AO353_20145 N.D.
Non functional Dihydropteroate synthase 2 No genes
Nucleoside triphosphate pyrophosphohydrolase MazG No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) AO353_01150 -0.0
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) AO353_00925 +0.2
PqqC-like protein No genes
Putative DHNTP pyrophosphatase No genes
Related to Dihydropteroate synthase No genes
Serine hydroxymethyltransferase (EC 2.1.2.1) AO353_07665 +0.1
  AO353_10495 -0.3
  AO353_10530 -0.2
  AO353_14020 N.D.
  AO353_14025 -0.1
  AO353_29335 -0.1
Substrate-specific component FolT of folate ECF transporter No genes
Thymidine kinase (EC 2.7.1.21) No genes
Thymidylate synthase (EC 2.1.1.45) AO353_08445 N.D.
Thymidylate synthase thyX (EC 2.1.1.-) No genes
Transaldolase (EC 2.2.1.2) AO353_00310 -1.5
Transmembrane component of general energizing module of ECF transporters No genes
Xanthosine/inosine triphosphate pyrophosphatase No genes
alternate gene name: yzbB AO353_19975 +0.0

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