SEED Subsystem: Folate Biosynthesis in Methanococcus maripaludis JJ

Role	Gene	Name	Formate McCas, 2.5g/L bicarb, 200 mM MOPs, 20 psi N2CO2, SO4 Vitamin & Casamino Acid FREE
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3)	No genes
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2)	No genes
5-nucleotidase SurE (EC 3.1.3.5)	MMJJ_RS08930		+1.7
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12)	No genes
ATPase component of general energizing module of ECF transporters	No genes
Alternative Folylglutamate Synthase	No genes
Alternative dihydrofolate reductase 2	No genes
Alternative dihydrofolate reductase 3	No genes
Aminodeoxychorismate lyase (EC 4.1.3.38)	No genes
COG0488: ATPase components of ABC transporters with duplicated ATPase domains	No genes
Dihydrofolate reductase (EC 1.5.1.3)	No genes
Dihydrofolate synthase (EC 6.3.2.12)	No genes
Dihydroneopterin aldolase (EC 4.1.2.25)	No genes
Dihydroneopterin triphosphate epimerase	No genes
Dihydroneopterin triphosphate pyrophosphohydolase	No genes
Dihydroneopterin triphosphate pyrophosphohydolase type 2	No genes
Dihydropteroate synthase (EC 2.5.1.15)	No genes
FolM Alternative dihydrofolate reductase 1	No genes
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB)	No genes
Folate transporter 3	No genes
Folylpolyglutamate synthase (EC 6.3.2.17)	No genes
Formate--tetrahydrofolate ligase (EC 6.3.4.3)	No genes
GTP cyclohydrolase I (EC 3.5.4.16) type 1	No genes
GTP cyclohydrolase I (EC 3.5.4.16) type 2	MMJJ_RS05265		N.D.
Methionyl-tRNA formyltransferase (EC 2.1.2.9)	No genes
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5)	No genes
Non functional Dihydropteroate synthase 2	No genes
Nucleoside triphosphate pyrophosphohydrolase MazG	No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85)	No genes
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85)	No genes
PqqC-like protein	No genes
Putative DHNTP pyrophosphatase	No genes
Related to Dihydropteroate synthase	MMJJ_RS06240		-4.1
Serine hydroxymethyltransferase (EC 2.1.2.1)	No genes
Substrate-specific component FolT of folate ECF transporter	No genes
Thymidine kinase (EC 2.7.1.21)	No genes
Thymidylate synthase (EC 2.1.1.45)	MMJJ_RS00030		+0.1
	MMJJ_RS07250		N.D.
Thymidylate synthase thyX (EC 2.1.1.-)	No genes
Transaldolase (EC 2.2.1.2)	MMJJ_RS07615		N.D.
Transmembrane component of general energizing module of ECF transporters	No genes
Xanthosine/inosine triphosphate pyrophosphatase	MMJJ_RS04195		-0.8
alternate gene name: yzbB	No genes