SEED Subsystem: Methionine Biosynthesis in Cupriavidus basilensis FW507-4G11

Experiments:

Role Gene Name L-Histidine (C)  
⨯
5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) RR42_RS01385 -5.0
5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) RR42_RS00770 -0.9
  RR42_RS00775 -1.0
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) RR42_RS30660 -3.8
Adenosylhomocysteinase (EC 3.3.1.1) RR42_RS01375 N.D.
  RR42_RS08855 +0.2
Archaeal S-adenosylmethionine synthetase (EC 2.5.1.6) RR42_RS35330 +0.2
Betaine--homocysteine S-methyltransferase (EC 2.1.1.5) No genes
Cystathionine beta-lyase (EC 4.4.1.8) RR42_RS07655 -0.3
  RR42_RS30610 -0.1
  RR42_RS31610 +0.1
Cystathionine beta-lyase, type II (EC 4.4.1.8) No genes
Cystathionine beta-synthase (EC 4.2.1.22) No genes
Cystathionine gamma-lyase (EC 4.4.1.1) No genes
Cystathionine gamma-synthase (EC 2.5.1.48) No genes
Cysteine synthase (EC 2.5.1.47) RR42_RS21960 +0.2
Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter No genes
Homocysteine S-methyltransferase (EC 2.1.1.10) No genes
Homoserine O-acetyltransferase (EC 2.3.1.31) RR42_RS01160 -4.5
Homoserine O-succinyltransferase (EC 2.3.1.46) No genes
Homoserine dehydrogenase (EC 1.1.1.3) RR42_RS12540 N.D.
Homoserine kinase (EC 2.7.1.39) RR42_RS15065 N.D.
Methionine ABC transporter ATP-binding protein RR42_RS00685 +0.0
  RR42_RS04555 -0.2
  RR42_RS09790 +0.4
Methionine ABC transporter permease protein RR42_RS04560 -0.5
Methionine ABC transporter substrate-binding protein RR42_RS03045 -0.5
  RR42_RS04565 -0.1
  RR42_RS28475 +0.3
  RR42_RS32615 -0.0
Methionine repressor MetJ No genes
Methionine synthase activation domain (EC 2.1.1.13) No genes
Methionine transporter MetT No genes
O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) RR42_RS06465 -0.1
  RR42_RS14320 -4.2
  RR42_RS32610 -0.1
O-succinylhomoserine sulfhydrylase (EC 2.5.1.48) RR42_RS06465 -0.1
  RR42_RS14320 -4.2
  RR42_RS32610 -0.1
Predicted regulator of methionine metabolism, ArsR family No genes
S-adenosylhomocysteine nucleosidase (EC 3.2.2.9) No genes
S-adenosylmethionine synthetase (EC 2.5.1.6) RR42_RS01265 N.D.
  RR42_RS01270 +0.2
S-ribosylhomocysteine lyase (EC 4.4.1.21) No genes
SAM-dependent methlytransferase UbiG No genes
SAM-dependent methlytransferase YrrT No genes
Serine acetyltransferase (EC 2.3.1.30) RR42_RS06325 -0.5
  RR42_RS15755 +0.3
Substrate-specific component MtsA of methionine-regulated ECF transporter No genes
Transcriptional activator MetR RR42_RS30655 -6.4
Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter No genes

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