SEED Subsystem: Folate Biosynthesis in Caulobacter crescentus NA1000

Role	Gene	Name	a-Cyclodextrin (C)
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3)	CCNA_01620		N.D.
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2)	CCNA_03354		+0.1
5-nucleotidase SurE (EC 3.1.3.5)	CCNA_02077		+0.7
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12)	No genes
ATPase component of general energizing module of ECF transporters	No genes
Alternative Folylglutamate Synthase	No genes
Alternative dihydrofolate reductase 2	No genes
Alternative dihydrofolate reductase 3	No genes
Aminodeoxychorismate lyase (EC 4.1.3.38)	CCNA_03047		-1.2
COG0488: ATPase components of ABC transporters with duplicated ATPase domains	CCNA_02714		+0.1
Dihydrofolate reductase (EC 1.5.1.3)	CCNA_02210		N.D.
Dihydrofolate synthase (EC 6.3.2.12)	No genes
Dihydroneopterin aldolase (EC 4.1.2.25)	CCNA_00421		N.D.
Dihydroneopterin triphosphate epimerase	No genes
Dihydroneopterin triphosphate pyrophosphohydolase	No genes
Dihydroneopterin triphosphate pyrophosphohydolase type 2	No genes
Dihydropteroate synthase (EC 2.5.1.15)	CCNA_03332		N.D.
FolM Alternative dihydrofolate reductase 1	CCNA_00422		-0.5
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB)	No genes
Folate transporter 3	No genes
Folylpolyglutamate synthase (EC 6.3.2.17)	No genes
Formate--tetrahydrofolate ligase (EC 6.3.4.3)	No genes
GTP cyclohydrolase I (EC 3.5.4.16) type 1	CCNA_00491		N.D.
GTP cyclohydrolase I (EC 3.5.4.16) type 2	No genes
Methionyl-tRNA formyltransferase (EC 2.1.2.9)	CCNA_00281		-2.6
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5)	CCNA_01275		N.D.
Non functional Dihydropteroate synthase 2	No genes
Nucleoside triphosphate pyrophosphohydrolase MazG	No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85)	CCNA_00414		+0.7
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85)	CCNA_03048		-1.5
PqqC-like protein	No genes
Putative DHNTP pyrophosphatase	No genes
Related to Dihydropteroate synthase	No genes
Serine hydroxymethyltransferase (EC 2.1.2.1)	CCNA_01419		N.D.
Substrate-specific component FolT of folate ECF transporter	No genes
Thymidine kinase (EC 2.7.1.21)	No genes
Thymidylate synthase (EC 2.1.1.45)	CCNA_02208		N.D.
Thymidylate synthase thyX (EC 2.1.1.-)	No genes
Transaldolase (EC 2.2.1.2)	CCNA_03729		-1.9
Transmembrane component of general energizing module of ECF transporters	No genes
Xanthosine/inosine triphosphate pyrophosphatase	No genes
alternate gene name: yzbB	No genes