| Role | Gene | Name | Nitrate reduction in presence of wild-type Pseudomonas N2-E3; replicate C | |
| | | ⨯ | |
| 5-aminolevulinate synthase (EC 2.3.1.37) | No genes | | | |
| Coproporphyrinogen III oxidase, aerobic (EC 1.3.3.3) | Pf6N2E2_4129 | | N.D. | |
| Coproporphyrinogen III oxidase, oxygen-independent (EC 1.3.99.22) | Pf6N2E2_1410 | | +0.2 | |
| | Pf6N2E2_1411 | | -1.4 | |
| | Pf6N2E2_2321 | | +0.3 | |
| Coproporphyrinogen III oxidase, oxygen-independent (EC 1.3.99.22), divergent, putative | No genes | | | |
| Coproporphyrinogen III oxidase, oxygen-independent (EC 1.3.99.22), divergent, putative 2 | No genes | | | |
| Distant homolog of E. coli HemX protein in Xanthomonadaceae | No genes | | | |
| Ferrochelatase, protoheme ferro-lyase (EC 4.99.1.1) | Pf6N2E2_5233 | | N.D. | |
| Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8) | Pf6N2E2_1739 | | -0.1 | |
| | Pf6N2E2_5022 | | N.D. | |
| Glutamyl-tRNA reductase (EC 1.2.1.70) | Pf6N2E2_5220 | | N.D. | |
| Glutamyl-tRNA synthetase (EC 6.1.1.17) | No genes | | | |
| HemX protein, negative effector of steady-state concentration of glutamyl-tRNA reductase | No genes | | | |
| Hemoprotein HemQ, essential component of heme biosynthetic pathway in Gram-positive bacteria | No genes | | | |
| Hypothetical membrane protein, possible involvement in cytochrome functioning/assembly | No genes | | | |
| Hypothetical radical SAM family enzyme, NOT coproporphyrinogen III oxidase, oxygen-independent | No genes | | | |
| Porphobilinogen deaminase (EC 2.5.1.61) | Pf6N2E2_4431 | | N.D. | |
| Porphobilinogen synthase (EC 4.2.1.24) | Pf6N2E2_2146 | | +0.2 | |
| | Pf6N2E2_4452 | | +0.2 | |
| Precorrin-2 oxidase (EC 1.3.1.76) | Pf6N2E2_302 | | -0.2 | |
| Protoporphyrinogen IX oxidase, aerobic (EC 1.3.3.4) | No genes | | | |
| Protoporphyrinogen IX oxidase, oxygen-independent, HemG (EC 1.3.-.-) | No genes | | | |
| Putative coproporphyrinogen III oxidase of BS HemN-type, oxygen-independent (EC 1.3.99.22), in heat shock gene cluster | No genes | | | |
| Radical SAM family enzyme, similar to coproporphyrinogen III oxidase, oxygen-independent, clustered with nucleoside-triphosphatase RdgB | Pf6N2E2_4593 | | +0.3 | |
| Radical SAM family protein HutW, similar to coproporphyrinogen III oxidase, oxygen-independent, associated with heme uptake | No genes | | | |
| Sirohydrochlorin ferrochelatase (EC 4.99.1.4) | Pf6N2E2_302 | | -0.2 | |
| Uroporphyrinogen III decarboxylase (EC 4.1.1.37) | Pf6N2E2_3750 | | N.D. | |
| Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) | Pf6N2E2_2381 | | -0.4 | |
| | Pf6N2E2_302 | | -0.2 | |
| | Pf6N2E2_696 | | -0.5 | |
| Uroporphyrinogen-III synthase (EC 4.2.1.75) | Pf6N2E2_4432 | | -0.1 | |
| Uroporphyrinogen-III synthase, divergent, Flavobacterial type (EC 4.2.1.75) | No genes | | | |
| Uroporphyrinogen-III synthase, divergent, Francisella type (EC 4.2.1.75) | No genes | | | |