SEED Subsystem: Folate Biosynthesis in Klebsiella michiganensis M5al

Experiments:

Role Gene Name Fungal_growth_media_mCAFEs_v1 with Supernatant; Trichoderma harzianum M10 grown in Fungal_growth_media_mCAFEs_v2, filtered and pH-adjusted 0.8 x  
⨯
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) BWI76_RS05000 N.D.
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) BWI76_RS23915 -0.6
5-nucleotidase SurE (EC 3.1.3.5) BWI76_RS03465 -0.0
  BWI76_RS22660 +0.0
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12) No genes
ATPase component of general energizing module of ECF transporters No genes
Alternative Folylglutamate Synthase No genes
Alternative dihydrofolate reductase 2 No genes
Alternative dihydrofolate reductase 3 No genes
Aminodeoxychorismate lyase (EC 4.1.3.38) BWI76_RS11105 -2.2
COG0488: ATPase components of ABC transporters with duplicated ATPase domains BWI76_RS03665 +1.4
  BWI76_RS09930 -0.4
Dihydrofolate reductase (EC 1.5.1.3) BWI76_RS04505 N.D.
  BWI76_RS12875 +0.7
Dihydrofolate synthase (EC 6.3.2.12) BWI76_RS20365 N.D.
Dihydroneopterin aldolase (EC 4.1.2.25) BWI76_RS24485 -4.2
Dihydroneopterin triphosphate epimerase BWI76_RS20295 +0.5
Dihydroneopterin triphosphate pyrophosphohydolase No genes
Dihydroneopterin triphosphate pyrophosphohydolase type 2 BWI76_RS18165 -0.3
Dihydropteroate synthase (EC 2.5.1.15) BWI76_RS25135 N.D.
FolM Alternative dihydrofolate reductase 1 BWI76_RS16230 -0.9
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB) No genes
Folate transporter 3 No genes
Folylpolyglutamate synthase (EC 6.3.2.17) BWI76_RS20365 N.D.
Formate--tetrahydrofolate ligase (EC 6.3.4.3) No genes
GTP cyclohydrolase I (EC 3.5.4.16) type 1 BWI76_RS19660 N.D.
GTP cyclohydrolase I (EC 3.5.4.16) type 2 No genes
Methionyl-tRNA formyltransferase (EC 2.1.2.9) BWI76_RS25675 N.D.
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) BWI76_RS07100 N.D.
Non functional Dihydropteroate synthase 2 No genes
Nucleoside triphosphate pyrophosphohydrolase MazG No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) BWI76_RS26005 -0.7
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) BWI76_RS17865 -1.5
PqqC-like protein No genes
Putative DHNTP pyrophosphatase No genes
Related to Dihydropteroate synthase No genes
Serine hydroxymethyltransferase (EC 2.1.2.1) BWI76_RS21225 N.D.
Substrate-specific component FolT of folate ECF transporter No genes
Thymidine kinase (EC 2.7.1.21) BWI76_RS17255 -0.8
Thymidylate synthase (EC 2.1.1.45) BWI76_RS14320 +0.7
Thymidylate synthase thyX (EC 2.1.1.-) No genes
Transaldolase (EC 2.2.1.2) BWI76_RS00820 +0.8
  BWI76_RS04270 -1.1
Transmembrane component of general energizing module of ECF transporters No genes
Xanthosine/inosine triphosphate pyrophosphatase No genes
alternate gene name: yzbB No genes

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