SEED Subsystem: Folate Biosynthesis in Pseudomonas fluorescens FW300-N2E2

Experiments:

Role Gene Name Cobalt chloride 0.6 mM  
⨯
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) Pf6N2E2_4797 -2.0
  Pf6N2E2_5154 N.D.
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) Pf6N2E2_4476 +0.5
5-nucleotidase SurE (EC 3.1.3.5) Pf6N2E2_3040 -1.4
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12) No genes
ATPase component of general energizing module of ECF transporters No genes
Alternative Folylglutamate Synthase No genes
Alternative dihydrofolate reductase 2 No genes
Alternative dihydrofolate reductase 3 No genes
Aminodeoxychorismate lyase (EC 4.1.3.38) Pf6N2E2_5955 -0.6
COG0488: ATPase components of ABC transporters with duplicated ATPase domains Pf6N2E2_2293 -0.6
Dihydrofolate reductase (EC 1.5.1.3) Pf6N2E2_4561 N.D.
Dihydrofolate synthase (EC 6.3.2.12) No genes
Dihydroneopterin aldolase (EC 4.1.2.25) Pf6N2E2_4796 N.D.
Dihydroneopterin triphosphate epimerase Pf6N2E2_5272 +2.3
Dihydroneopterin triphosphate pyrophosphohydolase No genes
Dihydroneopterin triphosphate pyrophosphohydolase type 2 No genes
Dihydropteroate synthase (EC 2.5.1.15) Pf6N2E2_3358 N.D.
FolM Alternative dihydrofolate reductase 1 Pf6N2E2_5274 +2.5
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB) No genes
Folate transporter 3 No genes
Folylpolyglutamate synthase (EC 6.3.2.17) No genes
Formate--tetrahydrofolate ligase (EC 6.3.4.3) No genes
GTP cyclohydrolase I (EC 3.5.4.16) type 1 Pf6N2E2_5273 +0.3
  Pf6N2E2_5815 N.D.
GTP cyclohydrolase I (EC 3.5.4.16) type 2 Pf6N2E2_4262 +0.1
Methionyl-tRNA formyltransferase (EC 2.1.2.9) Pf6N2E2_4122 N.D.
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) Pf6N2E2_2221 N.D.
Non functional Dihydropteroate synthase 2 No genes
Nucleoside triphosphate pyrophosphohydrolase MazG No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) Pf6N2E2_6001 -0.6
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) Pf6N2E2_6056 +0.3
PqqC-like protein No genes
Putative DHNTP pyrophosphatase No genes
Related to Dihydropteroate synthase No genes
Serine hydroxymethyltransferase (EC 2.1.2.1) Pf6N2E2_4717 +0.2
  Pf6N2E2_5082 N.D.
  Pf6N2E2_5083 -0.3
  Pf6N2E2_5295 +0.1
Substrate-specific component FolT of folate ECF transporter No genes
Thymidine kinase (EC 2.7.1.21) No genes
Thymidylate synthase (EC 2.1.1.45) Pf6N2E2_3946 N.D.
Thymidylate synthase thyX (EC 2.1.1.-) No genes
Transaldolase (EC 2.2.1.2) Pf6N2E2_2258 -1.7
Transmembrane component of general energizing module of ECF transporters No genes
Xanthosine/inosine triphosphate pyrophosphatase No genes
alternate gene name: yzbB No genes

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