SEED Subsystem: Folate Biosynthesis in Pseudomonas fluorescens SBW25-INTG

Experiments:

Role Gene Name Betaine (C)(N); with MOPS  
⨯
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) PFLU_RS25745 N.D.
  PFLU_RS27505 N.D.
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) PFLU_RS28965 -3.4
5-nucleotidase SurE (EC 3.1.3.5) PFLU_RS10890 -0.4
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12) No genes
ATPase component of general energizing module of ECF transporters No genes
Alternative Folylglutamate Synthase No genes
Alternative dihydrofolate reductase 2 No genes
Alternative dihydrofolate reductase 3 No genes
Aminodeoxychorismate lyase (EC 4.1.3.38) PFLU_RS23040 -2.0
COG0488: ATPase components of ABC transporters with duplicated ATPase domains No genes
Dihydrofolate reductase (EC 1.5.1.3) PFLU_RS18870 +0.0
  PFLU_RS28565 N.D.
Dihydrofolate synthase (EC 6.3.2.12) No genes
Dihydroneopterin aldolase (EC 4.1.2.25) PFLU_RS27510 N.D.
Dihydroneopterin triphosphate epimerase PFLU_RS25315 -0.5
Dihydroneopterin triphosphate pyrophosphohydolase No genes
Dihydroneopterin triphosphate pyrophosphohydolase type 2 No genes
Dihydropteroate synthase (EC 2.5.1.15) PFLU_RS25850 N.D.
FolM Alternative dihydrofolate reductase 1 PFLU_RS25305 -0.4
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB) No genes
Folate transporter 3 No genes
Folylpolyglutamate synthase (EC 6.3.2.17) No genes
Formate--tetrahydrofolate ligase (EC 6.3.4.3) No genes
GTP cyclohydrolase I (EC 3.5.4.16) type 1 PFLU_RS21315 -1.3
  PFLU_RS25310 -0.0
GTP cyclohydrolase I (EC 3.5.4.16) type 2 PFLU_RS29970 +0.0
Methionyl-tRNA formyltransferase (EC 2.1.2.9) PFLU_RS00085 N.D.
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) PFLU_RS11390 -0.2
  PFLU_RS11430 +0.1
  PFLU_RS19200 N.D.
Non functional Dihydropteroate synthase 2 No genes
Nucleoside triphosphate pyrophosphohydrolase MazG No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) PFLU_RS22835 -0.8
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) PFLU_RS22715 -1.8
PqqC-like protein No genes
Putative DHNTP pyrophosphatase No genes
Related to Dihydropteroate synthase No genes
Serine hydroxymethyltransferase (EC 2.1.2.1) PFLU_RS26190 -0.1
  PFLU_RS26195 N.D.
  PFLU_RS27825 -3.4
Substrate-specific component FolT of folate ECF transporter No genes
Thymidine kinase (EC 2.7.1.21) No genes
Thymidylate synthase (EC 2.1.1.45) PFLU_RS28625 N.D.
Thymidylate synthase thyX (EC 2.1.1.-) No genes
Transaldolase (EC 2.2.1.2) PFLU_RS07805 +0.0
  PFLU_RS10300 -0.1
  PFLU_RS18200 +0.0
Transmembrane component of general energizing module of ECF transporters No genes
Xanthosine/inosine triphosphate pyrophosphatase No genes
alternate gene name: yzbB No genes

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