MetaCyc Pathway: dTMP de novo biosynthesis (mitochondrial) in Pseudomonas fluorescens FW300-N2E2

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Dihydrofolate reductase (in reverse):
a 7,8-dihydrofolate + NADPH + H+→a tetrahydrofolate + NADP+ (EC 1.5.1.3)
Pf6N2E2_4561
Pf6N2E2_5274
Glycine hydroxymethyltransferase:
a tetrahydrofolate + L-serine→a 5,10-methylenetetrahydrofolate + glycine + H2O (EC 2.1.2.1)
Pf6N2E2_4717
Pf6N2E2_5082
Pf6N2E2_5083
Pf6N2E2_5295
Thymidylate synthase:
a 5,10-methylenetetrahydrofolate + dUMP→a 7,8-dihydrofolate + dTMP (EC 2.1.1.45)
Pf6N2E2_3946

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information