MetaCyc Pathway: noradrenaline and adrenaline degradation in Pseudomonas fluorescens FW300-N2E2

Add experiment(s):


Catechol O-methyltransferase:
(R)-noradrenaline + S-adenosyl-L-methionine→L-normetanephrine + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Monoamine oxidase:
(R)-noradrenaline + dioxygen + H2O→3,4-dihydroxyphenylglycolaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
Pf6N2E2_4632
Phenylethanolamine N-methyltransferase:
(R)-noradrenaline + S-adenosyl-L-methionine→(R)-adrenaline + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.28)
No genes
Monoamine oxidase:
(R)-adrenaline + dioxygen + H2O→3,4-dihydroxyphenylglycolaldehyde + hydrogen peroxide + methylamine (EC 1.4.3.4)
Pf6N2E2_4632
Catechol O-methyltransferase:
(R)-adrenaline + S-adenosyl-L-methionine→metanephrine + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Monoamine oxidase:
L-normetanephrine + dioxygen + H2O→3-methoxy-4-hydroxyphenylglycolaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
Pf6N2E2_4632
Alcohol dehydrogenase (in reverse):
3,4-dihydroxyphenylglycolaldehyde + NADH + H+→(R)-3,4-dihydroxyphenylglycol + NAD+ (EC 1.1.1.1)
Pf6N2E2_1380
Pf6N2E2_1522
Pf6N2E2_194
Pf6N2E2_2802
Pf6N2E2_3044
Pf6N2E2_4819
Pf6N2E2_5980
Pf6N2E2_840
Pf6N2E2_999
Aldehyde dehydrogenase (NAD(+)):
3,4-dihydroxyphenylglycolaldehyde + NAD+ + H2O→3,4-dihydroxymandelate + NADH + 2 H+ (EC 1.2.1.3)
Pf6N2E2_1381
Pf6N2E2_1764
Pf6N2E2_1854
Pf6N2E2_1874
Pf6N2E2_1878
Pf6N2E2_1906
Pf6N2E2_1919
Pf6N2E2_225
Pf6N2E2_3298
Pf6N2E2_351
Pf6N2E2_3582
Pf6N2E2_4383
Pf6N2E2_4964
Pf6N2E2_4979
Pf6N2E2_5476
Pf6N2E2_935
Monoamine oxidase:
metanephrine + dioxygen + H2O→3-methoxy-4-hydroxyphenylglycolaldehyde + hydrogen peroxide + methylamine (EC 1.4.3.4)
Pf6N2E2_4632
Catechol O-methyltransferase:
(R)-3,4-dihydroxyphenylglycol + S-adenosyl-L-methionine→3-methoxy-4-hydroxyphenylglycol + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Catechol O-methyltransferase:
3,4-dihydroxymandelate + S-adenosyl-L-methionine→vanillylmandelate + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Alcohol dehydrogenase:
3-methoxy-4-hydroxyphenylglycol + NAD+→3-methoxy-4-hydroxyphenylglycolaldehyde + NADH + H+ (EC 1.1.1.1)
Pf6N2E2_1380
Pf6N2E2_1522
Pf6N2E2_194
Pf6N2E2_2802
Pf6N2E2_3044
Pf6N2E2_4819
Pf6N2E2_5980
Pf6N2E2_840
Pf6N2E2_999
Aldehyde dehydrogenase (NAD(+)):
3-methoxy-4-hydroxyphenylglycolaldehyde + NAD+ + H2O→vanillylmandelate + NADH + 2 H+ (EC 1.2.1.3)
Pf6N2E2_1381
Pf6N2E2_1764
Pf6N2E2_1854
Pf6N2E2_1874
Pf6N2E2_1878
Pf6N2E2_1906
Pf6N2E2_1919
Pf6N2E2_225
Pf6N2E2_3298
Pf6N2E2_351
Pf6N2E2_3582
Pf6N2E2_4383
Pf6N2E2_4964
Pf6N2E2_4979
Pf6N2E2_5476
Pf6N2E2_935

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information