MetaCyc Pathway: serotonin degradation in Pseudomonas fluorescens FW300-N2E2

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Aryl sulfotransferase:
serotonin + 3'-phosphoadenylyl-sulfate→serotonin O-sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Monoamine oxidase:
serotonin + dioxygen + H2O→5-hydroxyindole acetaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
Pf6N2E2_4632
5-hydroxyindole acetaldehyde + L-cysteine→5-hydroxyindole thiazolidine carboxylate + H+ + H2O (spontaneous)
No genes
Aldehyde dehydrogenase (NAD(+)):
5-hydroxyindole acetaldehyde + NAD+ + H2O→5-hydroxyindole acetate + NADH + 2 H+ (EC 1.2.1.3)
Pf6N2E2_1381
Pf6N2E2_1764
Pf6N2E2_1854
Pf6N2E2_1874
Pf6N2E2_1878
Pf6N2E2_1906
Pf6N2E2_1919
Pf6N2E2_225
Pf6N2E2_3298
Pf6N2E2_351
Pf6N2E2_3582
Pf6N2E2_4383
Pf6N2E2_4964
Pf6N2E2_4979
Pf6N2E2_5476
Pf6N2E2_935
Alcohol dehydrogenase (in reverse):
5-hydroxyindole acetaldehyde + NADH + H+→5-hydroxytryptophol + NAD+ (EC 1.1.1.1)
Pf6N2E2_1380
Pf6N2E2_1522
Pf6N2E2_194
Pf6N2E2_2802
Pf6N2E2_3044
Pf6N2E2_4819
Pf6N2E2_5980
Pf6N2E2_840
Pf6N2E2_999
Aryl sulfotransferase:
5-hydroxytryptophol + 3'-phosphoadenylyl-sulfate→5-hydroxytryptophol sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Glucuronosyltransferase:
5-hydroxytryptophol + UDP-α-D-glucuronate→5-hydroxytryptophol glucuronide + H+ + UDP (EC 2.4.1.17)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information