MetaCyc Pathway: superpathway of glyoxylate cycle and fatty acid degradation in Pseudomonas fluorescens FW300-N2E2

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a 2,3,4-saturated fatty acid + ATP + coenzyme A→a 2,3,4-saturated fatty acyl CoA + AMP + diphosphate
No genes
Acyl-CoA oxidase:
a 2,3,4-saturated fatty acyl CoA + dioxygen→a (2E)-2-enoyl-CoA + hydrogen peroxide
(EC 1.3.3.6)
No genes
Enoyl-CoA hydratase (in reverse):
a (2E)-2-enoyl-CoA + H2O→a 2,3,4-saturated (3S)-3-hydroxyacyl-CoA
(EC 4.2.1.17)
Pf6N2E2_1013
Pf6N2E2_1046
Pf6N2E2_1147
Pf6N2E2_1149
Pf6N2E2_1269
Pf6N2E2_1833
Pf6N2E2_1834
Pf6N2E2_1835
Pf6N2E2_1840
Pf6N2E2_1850
Pf6N2E2_1922
Pf6N2E2_1934
Pf6N2E2_1935
Pf6N2E2_2290
Pf6N2E2_2773
Pf6N2E2_3894
Pf6N2E2_5493
Pf6N2E2_6000
Pf6N2E2_6004
Pf6N2E2_742
3-hydroxyacyl-CoA dehydrogenase:
a 2,3,4-saturated (3S)-3-hydroxyacyl-CoA + NAD+→a 2,3,4-saturated 3-oxoacyl-CoA + NADH + H+
(EC 1.1.1.35)
Pf6N2E2_1833
Pf6N2E2_1850
Pf6N2E2_1922
Pf6N2E2_2290
Pf6N2E2_3894
Pf6N2E2_4690
Pf6N2E2_6000
Acetyl-CoA C-acyltransferase (in reverse):
a 2,3,4-saturated 3-oxoacyl-CoA + coenzyme A→a 2,3,4-saturated fatty acyl CoA + acetyl-CoA
(EC 2.3.1.16)
Pf6N2E2_1145
Pf6N2E2_1675
Pf6N2E2_1836
Pf6N2E2_1851
Pf6N2E2_2113
Pf6N2E2_2289
Pf6N2E2_2539
Pf6N2E2_2835
Pf6N2E2_3492
Pf6N2E2_5999
Citrate (Si)-synthase:
acetyl-CoA + oxaloacetate + H2O→citrate + coenzyme A + H+
(EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
Pf6N2E2_5850
Aconitate hydratase:
citrate→cis-aconitate + H2O
(EC 4.2.1.3)
Pf6N2E2_2301
Pf6N2E2_564
Pf6N2E2_6063
Aconitate hydratase:
cis-aconitate + H2O→D-threo-isocitrate
(EC 4.2.1.3)
Pf6N2E2_2301
Pf6N2E2_564
Pf6N2E2_6063
Isocitrate lyase:
D-threo-isocitrate→glyoxylate + succinate
(EC 4.1.3.1)
Pf6N2E2_279
Malate synthase:
acetyl-CoA + glyoxylate + H2O→(S)-malate + coenzyme A + H+
(EC 2.3.3.9)
Pf6N2E2_4752
Succinate dehydrogenase (ubiquinone):
succinate[in] + an electron-transfer quinone→fumarate[in] + an electron-transfer quinol
(EC 1.3.5.1)
Pf6N2E2_5852
Pf6N2E2_5853
Pf6N2E2_5854
Fumarate hydratase (in reverse):
fumarate + H2O→(S)-malate
(EC 4.2.1.2)
Pf6N2E2_2536
Pf6N2E2_3276
Pf6N2E2_5489
Malate dehydrogenase:
(S)-malate + NAD+→oxaloacetate + NADH + H+
(EC 1.1.1.37; 1.1.1.38)
No genes
Phosphoenolpyruvate carboxykinase (ATP):
oxaloacetate + ATP→phosphoenolpyruvate + ADP + CO2
(EC 4.1.1.49)
Pf6N2E2_3899

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information