MetaCyc Pathway: superpathway of L-lysine, L-threonine and L-methionine biosynthesis I in Pseudomonas fluorescens FW300-N2E2

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Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate
(EC 2.6.1.1)
Pf6N2E2_1496
Pf6N2E2_2127
Pf6N2E2_2446
Pf6N2E2_2632
Pf6N2E2_3173
Pf6N2E2_4288
Pf6N2E2_4386
Pf6N2E2_462
Pf6N2E2_5300
Pf6N2E2_5813
Pf6N2E2_5890
Pf6N2E2_5891
Pf6N2E2_5895
Pf6N2E2_5989
Pf6N2E2_637
Pf6N2E2_684
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP
(EC 2.7.2.4)
Pf6N2E2_5676
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate
(EC 1.2.1.11)
Pf6N2E2_2844
Pf6N2E2_4232
Pf6N2E2_67
Pf6N2E2_68
L-aspartate 4-semialdehyde + pyruvate→(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + H2O (EC 4.3.3.7)
Pf6N2E2_2747
Pf6N2E2_3203
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+
(EC 1.1.1.3)
Pf6N2E2_3143
Pf6N2E2_4963
Homoserine kinase:
L-homoserine + ATP→O-phospho-L-homoserine + ADP + H+
(EC 2.7.1.39)
Pf6N2E2_4164
Pf6N2E2_6055
Homoserine O-succinyltransferase:
L-homoserine + succinyl-CoA→O-succinyl-L-homoserine + coenzyme A
(EC 2.3.1.46)
No genes
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+→(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ + H2O (EC 1.17.1.8)
Pf6N2E2_3366
Cystathionine gamma-synthase:
O-succinyl-L-homoserine + L-cysteine→L-cystathionine + H+ + succinate
(EC 2.5.1.48)
Pf6N2E2_4958
Pf6N2E2_77
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase:
(S)-2,3,4,5-tetrahydrodipicolinate + succinyl-CoA + H2ON-succinyl-2-amino-6-ketopimelate + coenzyme A
(EC 2.3.1.117)
Pf6N2E2_3078
Threonine synthase:
O-phospho-L-homoserine + H2O→L-threonine + phosphate
(EC 4.2.3.1)
Pf6N2E2_3142
Pf6N2E2_4961
Pf6N2E2_5296
Cysteine-S-conjugate beta-lyase:
L-cystathionine + H2O→L-homocysteine + ammonium + pyruvate
(EC 4.4.1.13)
No genes
Succinyldiaminopimelate transaminase (in reverse):
N-succinyl-2-amino-6-ketopimelate + L-glutamateN-succinyl-L,L-2,6-diaminopimelate + 2-oxoglutarate
(EC 2.6.1.17)
Pf6N2E2_3073
Pf6N2E2_5665
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase:
L-homocysteine + 5-methyltetrahydropteroyl tri-L-glutamate→L-methionine + tetrahydropteroyl tri-L-glutamate
(EC 2.1.1.14)
Pf6N2E2_5472
Methionine synthase:
L-homocysteine + a 5-methyltetrahydrofolate→L-methionine + a tetrahydrofolate
(EC 2.1.1.13)
Pf6N2E2_2068
Succinyl-diaminopimelate desuccinylase:
N-succinyl-L,L-2,6-diaminopimelate + H2O→L,L-diaminopimelate + succinate
(EC 3.5.1.18)
Pf6N2E2_3083
Diaminopimelate epimerase:
L,L-diaminopimelate→meso-diaminopimelate
(EC 5.1.1.7)
Pf6N2E2_2885
Pf6N2E2_33
Pf6N2E2_4418
Pf6N2E2_6030
Pf6N2E2_758
Diaminopimelate decarboxylase:
meso-diaminopimelate + H+→L-lysine + CO2
(EC 4.1.1.20)
Pf6N2E2_4419

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information