MetaCyc Pathway: L-tyrosine degradation I in Pseudomonas fluorescens FW300-N2E3

Add experiment(s):


Aspartate transaminase:
L-tyrosine + 2-oxoglutarate→3-(4-hydroxyphenyl)pyruvate + L-glutamate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)
AO353_01120
AO353_01210
AO353_01655
AO353_02065
AO353_02295
AO353_05105
AO353_09180
AO353_09990
AO353_15915
AO353_17700
AO353_18575
AO353_19150
AO353_20540
AO353_20995
AO353_22840
AO353_22920
AO353_23080
AO353_24850
AO353_26890
AO353_28150
AO353_29325
4-hydroxyphenylpyruvate dioxygenase:
3-(4-hydroxyphenyl)pyruvate + dioxygen→homogentisate + CO2 (EC 1.13.11.27)
AO353_06185
AO353_26925
Homogentisate 1,2-dioxygenase:
homogentisate + dioxygen→4-maleyl-acetoacetate + H+ (EC 1.13.11.5)
AO353_15550
Maleylacetoacetate isomerase:
4-maleyl-acetoacetate→4-fumaryl-acetoacetate (EC 5.2.1.2)
AO353_15560
Fumarylacetoacetase:
4-fumaryl-acetoacetate + H2O→acetoacetate + fumarate + H+ (EC 3.7.1.2)
AO353_15555

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information