MetaCyc Pathway: 4-oxopentanoate degradation in Pseudomonas fluorescens FW300-N2E3

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Butyrate--CoA ligase:
4-oxopentanoate + ATP + coenzyme A→4-oxopentanoyl-CoA + AMP + diphosphate (EC 6.2.1.2)
No genes
Butyrate--CoA ligase:
4-hydroxypentanoate + ATP + coenzyme A→4-hydroxypentanoyl-CoA + AMP + diphosphate (EC 6.2.1.2)
No genes
4-oxopentanoyl-CoA + NAD(P)H + H+→4-hydroxypentanoyl-CoA + NAD(P)+ (EC 1.1.1.M44)
No genes
4-hydroxypentanoyl-CoA + ATP→4-(phosphooxy)pentanoyl-CoA + ADP + H+ (EC 2.7.1.M16)
No genes
4-(phosphooxy)pentanoyl-CoA→3-pentenoyl-CoA + phosphate (EC 5.4.4.M2)
No genes
3-pentenoyl-CoA→(2E)-pent-2-enoyl-CoA (EC 5.4.4.M2)
No genes
(2E)-pent-2-enoyl-CoA + H2O→(3R)-3-hydroxypentanoyl-CoA (EC 5.4.4.M2)
No genes
Acetoacetyl-CoA reductase:
(3R)-3-hydroxypentanoyl-CoA + NADP+→3-oxopentanoyl-CoA + NADPH + H+ (EC 1.1.1.36)
AO353_00510
AO353_01060
Acetyl-CoA C-acyltransferase (in reverse):
3-oxopentanoyl-CoA + coenzyme A→propanoyl-CoA + acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
AO353_00505
AO353_01065
AO353_01160
AO353_05785
AO353_13880
AO353_17205
AO353_25685
AO353_27530
AO353_27945

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information