MetaCyc Pathway: ketogenesis in Pseudomonas fluorescens FW300-N1B4

Add experiment(s):


Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
Pf1N1B4_1270
Pf1N1B4_3234
Pf1N1B4_371
Pf1N1B4_3795
Pf1N1B4_3904
Pf1N1B4_4786
Pf1N1B4_5133
Pf1N1B4_5589
Pf1N1B4_5835
Hydroxymethylglutaryl-CoA synthase:
acetoacetyl-CoA + acetyl-CoA + H2O→(S)-3-hydroxy-3-methylglutaryl-CoA + coenzyme A + H+ (EC 2.3.3.10)
No genes
Hydroxymethylglutaryl-CoA lyase:
(S)-3-hydroxy-3-methylglutaryl-CoA→acetyl-CoA + acetoacetate (EC 4.1.3.4)
Pf1N1B4_3273
Pf1N1B4_3990
3-hydroxybutyrate dehydrogenase (in reverse):
acetoacetate + NADH + H+→(R)-3-hydroxybutanoate + NAD+ (EC 1.1.1.30)
Pf1N1B4_4556
Pf1N1B4_5077
Pf1N1B4_5633
Acetoacetate decarboxylase:
acetoacetate + H+→acetone + CO2 (EC 4.1.1.4)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information