MetaCyc Pathway: noradrenaline and adrenaline degradation in Pseudomonas fluorescens FW300-N1B4

Add experiment(s):


Catechol O-methyltransferase:
(R)-noradrenaline + S-adenosyl-L-methionine→L-normetanephrine + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Monoamine oxidase:
(R)-noradrenaline + dioxygen + H2O→3,4-dihydroxyphenylglycolaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
Pf1N1B4_2378
Phenylethanolamine N-methyltransferase:
(R)-noradrenaline + S-adenosyl-L-methionine→(R)-adrenaline + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.28)
No genes
Monoamine oxidase:
(R)-adrenaline + dioxygen + H2O→3,4-dihydroxyphenylglycolaldehyde + hydrogen peroxide + methylamine (EC 1.4.3.4)
Pf1N1B4_2378
Catechol O-methyltransferase:
(R)-adrenaline + S-adenosyl-L-methionine→metanephrine + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Monoamine oxidase:
L-normetanephrine + dioxygen + H2O→3-methoxy-4-hydroxyphenylglycolaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
Pf1N1B4_2378
Alcohol dehydrogenase (in reverse):
3,4-dihydroxyphenylglycolaldehyde + NADH + H+→(R)-3,4-dihydroxyphenylglycol + NAD+ (EC 1.1.1.1)
Pf1N1B4_2542
Pf1N1B4_3108
Pf1N1B4_3270
Pf1N1B4_395
Pf1N1B4_4176
Pf1N1B4_4243
Pf1N1B4_4506
Pf1N1B4_4898
Pf1N1B4_5026
Aldehyde dehydrogenase (NAD(+)):
3,4-dihydroxyphenylglycolaldehyde + NAD+ + H2O→3,4-dihydroxymandelate + NADH + 2 H+ (EC 1.2.1.3)
Pf1N1B4_1109
Pf1N1B4_1384
Pf1N1B4_171
Pf1N1B4_2132
Pf1N1B4_2315
Pf1N1B4_2673
Pf1N1B4_4244
Pf1N1B4_4502
Pf1N1B4_4920
Pf1N1B4_695
Monoamine oxidase:
metanephrine + dioxygen + H2O→3-methoxy-4-hydroxyphenylglycolaldehyde + hydrogen peroxide + methylamine (EC 1.4.3.4)
Pf1N1B4_2378
Catechol O-methyltransferase:
(R)-3,4-dihydroxyphenylglycol + S-adenosyl-L-methionine→3-methoxy-4-hydroxyphenylglycol + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Catechol O-methyltransferase:
3,4-dihydroxymandelate + S-adenosyl-L-methionine→vanillylmandelate + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Alcohol dehydrogenase:
3-methoxy-4-hydroxyphenylglycol + NAD+→3-methoxy-4-hydroxyphenylglycolaldehyde + NADH + H+ (EC 1.1.1.1)
Pf1N1B4_2542
Pf1N1B4_3108
Pf1N1B4_3270
Pf1N1B4_395
Pf1N1B4_4176
Pf1N1B4_4243
Pf1N1B4_4506
Pf1N1B4_4898
Pf1N1B4_5026
Aldehyde dehydrogenase (NAD(+)):
3-methoxy-4-hydroxyphenylglycolaldehyde + NAD+ + H2O→vanillylmandelate + NADH + 2 H+ (EC 1.2.1.3)
Pf1N1B4_1109
Pf1N1B4_1384
Pf1N1B4_171
Pf1N1B4_2132
Pf1N1B4_2315
Pf1N1B4_2673
Pf1N1B4_4244
Pf1N1B4_4502
Pf1N1B4_4920
Pf1N1B4_695

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information