MetaCyc Pathway: superpathway of coenzyme A biosynthesis I (bacteria) in Pseudomonas stutzeri RCH2

MetaCyc Pathway: superpathway of coenzyme A biosynthesis I (bacteria) in Pseudomonas stutzeri RCH2

3-methyl-2-oxobutanoate hydroxymethyltransferase:
3-methyl-2-oxobutanoate + a 5,10-methylenetetrahydrofolate + H₂O→2-dehydropantoate + a tetrahydrofolate (EC 2.1.2.11)

Aspartate 1-decarboxylase:
L-aspartate + H⁺→β-alanine + CO₂ (EC 4.1.1.11)

2-dehydropantoate 2-reductase (in reverse):
2-dehydropantoate + NADPH + H⁺→(R)-pantoate + NADP⁺ (EC 1.1.1.169)

Pantoate--beta-alanine ligase:
β-alanine + (R)-pantoate + ATP→(R)-pantothenate + AMP + diphosphate + H⁺ (EC 6.3.2.1)

Pantothenate kinase:
(R)-pantothenate + ATP→(R)-4'-phosphopantothenate + ADP + H⁺ (EC 2.7.1.33)

Phosphopantothenate--cysteine ligase:
(R)-4'-phosphopantothenate + CTP + L-cysteine→(R)-4'-phosphopantothenoyl-L-cysteine + CMP + diphosphate + H⁺ (EC 6.3.2.5)

Phosphopantothenoylcysteine decarboxylase:
(R)-4'-phosphopantothenoyl-L-cysteine + H⁺→4'-phosphopantetheine + CO₂ (EC 4.1.1.36)

Pantetheine-phosphate adenylyltransferase:
4'-phosphopantetheine + ATP + H⁺→3'-dephospho-CoA + diphosphate (EC 2.7.7.3)

Dephospho-CoA kinase:
3'-dephospho-CoA + ATP→coenzyme A + ADP + H⁺ (EC 2.7.1.24)

Links:

Pathway details at MetaCyc
Fitness data for 10 genes
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All MetaCyc pathways for Pseudomonas stutzeri RCH2

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information