MetaCyc Pathway: superpathway of anaerobic energy metabolism (invertebrates) in Azospirillum brasilense Sp245

MetaCyc Pathway: superpathway of anaerobic energy metabolism (invertebrates) in Azospirillum brasilense Sp245

Phosphoenolpyruvate carboxykinase (GTP) (in reverse):
phosphoenolpyruvate + CO₂ + GDP→oxaloacetate + GTP (EC 4.1.1.32)

Pyruvate kinase (in reverse):
phosphoenolpyruvate + ADP + H⁺→pyruvate + ATP (EC 2.7.1.40)

Phosphoenolpyruvate carboxykinase (GTP) (in reverse):
phosphoenolpyruvate + CO₂ + IDP→oxaloacetate + ITP (EC 4.1.1.32)

Alanine transaminase (in reverse):
pyruvate + L-glutamate→2-oxoglutarate + L-alanine (EC 2.6.1.2)

No genes

Malate dehydrogenase (in reverse):
oxaloacetate + NADH + H⁺→(S)-malate + NAD⁺ (EC 1.1.1.37; 1.1.1.38)

Malate dehydrogenase (oxaloacetate-decarboxylating):
(S)-malate + NAD⁺→pyruvate + CO₂ + NADH (EC 1.1.1.38)

No genes

Alanine racemase:
L-alanine→D-alanine (EC 5.1.1.1; 5.1.1.10)

Aspartate transaminase:
2-oxoglutarate + L-aspartate→L-glutamate + oxaloacetate (EC 2.6.1.1)

Fumarate hydratase:
(S)-malate→fumarate + H₂O (EC 4.2.1.2)

pyruvate + coenzyme A + NAD⁺→CO₂ + acetyl-CoA + NADH (EC 1.2.1.104)

Succinate dehydrogenase (ubiquinone) (in reverse):
fumarate_[in] + a rhodoquinol→succinate_[in] + a rhodoquinone (EC 1.3.5.1)

No genes

acetyl-CoA + succinate→acetate + succinyl-CoA (EC 2.8.3.18)

succinate + propanoyl-CoA→succinyl-CoA + propanoate (EC 2.8.3.27)

No genes

Methylmalonyl-CoA mutase (in reverse):
succinyl-CoA→(R)-methylmalonyl-CoA (EC 5.4.99.2)

Succinate--CoA ligase (ADP-forming) (in reverse):
succinyl-CoA + ADP + phosphate→succinate + ATP + coenzyme A (EC 6.2.1.5)

Methylmalonyl-CoA epimerase:
(R)-methylmalonyl-CoA→(S)-methylmalonyl-CoA (EC 5.1.99.1)

Propionyl-CoA carboxylase (in reverse):
(S)-methylmalonyl-CoA + ADP + H⁺ + phosphate→propanoyl-CoA + ATP + hydrogen carbonate (EC 6.4.1.3)

Links:

Pathway details at MetaCyc
Fitness data for 35 genes
Select organism:
All MetaCyc pathways for Azospirillum brasilense Sp245

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information