MetaCyc Pathway: aclacinomycin biosynthesis in Azospirillum brasilense Sp245

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propanoyl-CoA + 9 malonyl-CoA + 9 H+ + a holo acp domain within a [polyketide synthase]→3,5,7,9,11,13,15,17,19-nonaoxohenicosanoyl-[acp] + 9 CO2 + 10 coenzyme A
No genes
3,5,7,9,11,13,15,17,19-nonaoxohenicosanoyl-[acp] + NADPH + H+→9-hydroxy-3,5,7,11,13,15,17,19-octaoxohenicosanoyl-[acp] + NADP+
AZOBR_RS16640
AZOBR_RS27005
9-hydroxy-3,5,7,11,13,15,17,19-octaoxohenicosanoyl-[acp]→6-[3-hydroxy-2-(3,5,7-trioxononanoyl)phenyl]-3,5-dioxohexanoate + H+ + a holo acp domain within a [polyketide synthase] + H2O
No genes
6-[3-hydroxy-2-(3,5,7-trioxononanoyl)phenyl]-3,5-dioxohexanoate→12-deoxyaklanoate + 2 H2O
No genes
12-deoxyaklanoate + dioxygen→aklanonate + H2O
No genes
aklanonate + S-adenosyl-L-methionine→methyl aklanonate + S-adenosyl-L-homocysteine (EC 2.1.1.288)
No genes
methyl aklanonate→aklaviketone (EC 5.5.1.23)
No genes
aklaviketone + NADPH + H+→aklavinone + NADP+ (EC 1.1.1.362)
No genes
aklavinone + dTDP-β-L-rhodosamine→aclacinomycin T + H+ + dTDP (EC 2.4.1.326)
No genes
aclacinomycin T + dTDP-2-deoxy-β-L-fucose→aclacinomycin S + H+ + dTDP (EC 2.4.1.327)
No genes
aclacinomycin S + dTDP-L-rhodinose→aclacinomycin N + H+ + dTDP (EC 2.4.1.327)
No genes
aclacinomycin N + dioxygen→aclacinomycin A + hydrogen peroxide (EC 1.1.3.45)
No genes
aclacinomycin A + dioxygen→aclacinomycin Y + hydrogen peroxide (EC 1.3.3.14)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information