| propanoyl-CoA + 9 malonyl-CoA + 9 H+ + a holo acp domain within a [polyketide synthase]→3,5,7,9,11,13,15,17,19-nonaoxohenicosanoyl-[acp] + 9 CO2 + 10 coenzyme A |
| No genes |
| 3,5,7,9,11,13,15,17,19-nonaoxohenicosanoyl-[acp] + NADPH + H+→9-hydroxy-3,5,7,11,13,15,17,19-octaoxohenicosanoyl-[acp] + NADP+ |
| AZOBR_RS16640 |
| AZOBR_RS27005 |
| 9-hydroxy-3,5,7,11,13,15,17,19-octaoxohenicosanoyl-[acp]→6-[3-hydroxy-2-(3,5,7-trioxononanoyl)phenyl]-3,5-dioxohexanoate + H+ + a holo acp domain within a [polyketide synthase] + H2O |
| No genes |
| 6-[3-hydroxy-2-(3,5,7-trioxononanoyl)phenyl]-3,5-dioxohexanoate→12-deoxyaklanoate + 2 H2O |
| No genes |
| 12-deoxyaklanoate + dioxygen→aklanonate + H2O |
| No genes |
| aklanonate + S-adenosyl-L-methionine→methyl aklanonate + S-adenosyl-L-homocysteine (EC 2.1.1.288) |
| No genes |
| methyl aklanonate→aklaviketone (EC 5.5.1.23) |
| No genes |
| aklaviketone + NADPH + H+→aklavinone + NADP+ (EC 1.1.1.362) |
| No genes |
| aklavinone + NADPH + dioxygen + H+→ε-rhodomycinone + NADP+ + H2O (EC 1.14.13.180) |
| No genes |
| ε-rhodomycinone + dTDP-L-daunosamine→rhodomycinone D + H+ + dTDP |
| No genes |
| rhodomycinone D + H2O→10-carboxy-3-deoxycarminomycin + methanol + H+ |
| No genes |
| 10-carboxy-3-deoxycarminomycin + H+→13-deoxycarminomycin + CO2 (spontaneous) |
| No genes |
| 13-deoxycarminomycin + S-adenosyl-L-methionine→13-deoxydaunorubicin + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.292) |
| No genes |
| 13-deoxycarminomycin + NADPH + dioxygen + H+→13-dihydrocarminomycin + NADP+ + H2O (EC 1.14.13.181) |
| No genes |
| 13-deoxydaunorubicin + NADPH + dioxygen + H+→13-dihydrodaunorubicin + NADP+ + H2O (EC 1.14.13.181) |
| No genes |
| 13-dihydrocarminomycin + S-adenosyl-L-methionine→13-dihydrodaunorubicin + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.292) |
| No genes |
| 13-dihydrocarminomycin + NADPH + dioxygen + H+→carminomycin + NADP+ + 2 H2O (EC 1.14.13.181) |
| No genes |
| carminomycin + S-adenosyl-L-methionine→daunorubicin + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.292) |
| No genes |
| 13-dihydrodaunorubicin + NADPH + dioxygen + H+→daunorubicin + NADP+ + 2 H2O (EC 1.14.13.181) |
| No genes |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information