MetaCyc Pathway: 8-amino-7-oxononanoate biosynthesis I in Azospirillum brasilense Sp245

Add experiment(s):


a malonyl-[acp] + S-adenosyl-L-methionine→a malonyl-[acp] methyl ester + S-adenosyl-L-homocysteine (EC 2.1.1.197)
No genes
Beta-ketoacyl-acyl-carrier-protein synthase II:
a malonyl-[acp] + a malonyl-[acp] methyl ester + H+→a 3-oxoglutaryl-[acp] methyl ester + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
AZOBR_RS04690
AZOBR_RS04705
AZOBR_RS08400
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxoglutaryl-[acp] methyl ester + NADPH + H+→a (3R)-3-hydroxyglutaryl-[acp] methyl ester + NADP+ (EC 1.1.1.100)
AZOBR_RS04635
AZOBR_RS04695
AZOBR_RS05905
AZOBR_RS08305
AZOBR_RS08390
AZOBR_RS09155
AZOBR_RS09410
AZOBR_RS13310
AZOBR_RS16265
AZOBR_RS18775
AZOBR_RS21545
AZOBR_RS21600
AZOBR_RS22705
AZOBR_RS24695
AZOBR_RS25420
AZOBR_RS25730
AZOBR_RS25910
AZOBR_RS26450
AZOBR_RS27545
AZOBR_RS27580
AZOBR_RS27660
AZOBR_RS28175
AZOBR_RS29790
AZOBR_RS30020
AZOBR_RS31580
AZOBR_RS32755
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyglutaryl-[acp] methyl ester→a (2E)-enoylglutaryl-[acp] methyl ester + H2O (EC 4.2.1.59)
AZOBR_RS07370
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-enoylglutaryl-[acp] methyl ester + NADH + H+→a glutaryl-[acp] methyl ester + NAD+ (EC 1.3.1.9)
AZOBR_RS08105
AZOBR_RS09570
AZOBR_RS10720
AZOBR_RS18895
Beta-ketoacyl-acyl-carrier-protein synthase II:
a glutaryl-[acp] methyl ester + a malonyl-[acp] + H+→a 3-oxopimeloyl-[acp] methyl ester + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
AZOBR_RS04690
AZOBR_RS04705
AZOBR_RS08400
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxopimeloyl-[acp] methyl ester + NADPH + H+→a (3R)-3-hydroxypimeloyl-[acp] methyl ester + NADP+ (EC 1.1.1.100)
AZOBR_RS04635
AZOBR_RS04695
AZOBR_RS05905
AZOBR_RS08305
AZOBR_RS08390
AZOBR_RS09155
AZOBR_RS09410
AZOBR_RS13310
AZOBR_RS16265
AZOBR_RS18775
AZOBR_RS21545
AZOBR_RS21600
AZOBR_RS22705
AZOBR_RS24695
AZOBR_RS25420
AZOBR_RS25730
AZOBR_RS25910
AZOBR_RS26450
AZOBR_RS27545
AZOBR_RS27580
AZOBR_RS27660
AZOBR_RS28175
AZOBR_RS29790
AZOBR_RS30020
AZOBR_RS31580
AZOBR_RS32755
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxypimeloyl-[acp] methyl ester→a (2E)-enoylpimeloyl-[acp] methyl ester + H2O (EC 4.2.1.59)
AZOBR_RS07370
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-enoylpimeloyl-[acp] methyl ester + NADH + H+→a pimeloyl-[acp] methyl ester + NAD+ (EC 1.3.1.9)
AZOBR_RS08105
AZOBR_RS09570
AZOBR_RS10720
AZOBR_RS18895
a pimeloyl-[acp] methyl ester + H2O→a pimeloyl-[acp] + methanol + H+ (EC 3.1.1.85)
No genes
8-amino-7-oxononanoate synthase:
a pimeloyl-[acp] + L-alanine + H+→(8S)-8-amino-7-oxononanoate + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.47)
AZOBR_RS31105

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information