MetaCyc Pathway: superpathway of methylglyoxal degradation in Azospirillum brasilense Sp245

Add experiment(s):


Methylglyoxal reductase (NADPH-dependent) (in reverse):
methylglyoxal + NADPH + H+→(S)-lactaldehyde + NADP+ (EC 1.1.1.283)
No genes
Lactoylglutathione lyase (in reverse):
methylglyoxal + glutathione→(R)-S-lactoylglutathione (EC 4.4.1.5)
AZOBR_RS00775
AZOBR_RS07390
AZOBR_RS29310
AZOBR_RS31635
Aldehyde reductase (in reverse):
methylglyoxal + NADPH + H+→hydroxyacetone + NADP+ (EC 1.1.1.21)
AZOBR_RS19710
AZOBR_RS31410
Hydroxyacylglutathione hydrolase:
(R)-S-lactoylglutathione + H2O→(R)-lactate + glutathione + H+ (EC 3.1.2.6)
AZOBR_RS07730
AZOBR_RS16010
AZOBR_RS16510
AZOBR_RS19250
AZOBR_RS20450
AZOBR_RS20455
Lactaldehyde dehydrogenase:
(S)-lactaldehyde + NAD+ + H2O→(S)-lactate + NADH + 2 H+ (EC 1.2.1.22)
AZOBR_RS09720
AZOBR_RS19635
AZOBR_RS29750
AZOBR_RS32620
hydroxyacetone + NADH + H+→(S)-propane-1,2-diol + NAD+
AZOBR_RS07845
(S)-lactate[in] + an electron-transfer quinone→pyruvate[in] + an electron-transfer quinol (EC 1.1.5.M6)
No genes
(R)-lactate[in] + an electron-transfer quinone→pyruvate[in] + an electron-transfer quinol (EC 1.1.5.12)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information