MetaCyc Pathway: D-glucuronate degradation II in Acidovorax sp. GW101-3H11

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Uronate dehydrogenase:
β-D-glucuronate + NAD+→D-glucaro-1,5-lactone + NADH + H+ (EC 1.1.1.203)
Ac3H11_3958
D-glucaro-1,5-lactone→D-glucaro-1,4-lactone (spontaneous) (EC 5.4.1.4)
No genes
D-glucaro-1,4-lactone→5-dehydro-4-deoxy-D-glucarate + H+ (EC 5.5.1.27)
No genes
5-dehydro-4-deoxyglucarate dehydratase:
5-dehydro-4-deoxy-D-glucarate + H+→2,5-dioxopentanoate + CO2 + H2O (EC 4.2.1.41)
Ac3H11_2339
Ac3H11_336
2,5-dioxovalerate dehydrogenase:
2,5-dioxopentanoate + NADP+ + H2O→2-oxoglutarate + NADPH + 2 H+ (EC 1.2.1.26)
Ac3H11_255
Ac3H11_3961
Ac3H11_612

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information