MetaCyc Pathway: L-lysine biosynthesis II in Vibrio cholerae E7946 ATCC 55056

Add experiment(s):


Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP
(EC 2.7.2.4)
CSW01_02065
CSW01_02890
CSW01_11975
CSW01_13555
CSW01_18265
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate
(EC 1.2.1.11)
CSW01_10175
CSW01_10520
L-aspartate 4-semialdehyde + pyruvate→(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + H2O (EC 4.3.3.7)
CSW01_10755
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+→(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ + H2O (EC 1.17.1.8)
CSW01_12115
Tetrahydrodipicolinate N-acetyltransferase:
(S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O→L-2-acetamido-6-oxoheptanedioate + coenzyme A
(EC 2.3.1.89)
No genes
L-2-acetamido-6-oxoheptanedioate + L-glutamateN-acetyl-L,L-2,6-diaminopimelate + 2-oxoglutarate
No genes
N-acetyldiaminopimelate deacetylase:
N-acetyl-L,L-2,6-diaminopimelate + H2O→L,L-diaminopimelate + acetate
(EC 3.5.1.47)
No genes
Diaminopimelate epimerase:
L,L-diaminopimelate→meso-diaminopimelate
(EC 5.1.1.7)
CSW01_00640
CSW01_18625
Diaminopimelate decarboxylase:
meso-diaminopimelate + H+→L-lysine + CO2
(EC 4.1.1.20)
CSW01_00635

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information