MetaCyc Pathway: erythro-tetrahydrobiopterin biosynthesis I in Synechococcus elongatus PCC 7942

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GTP cyclohydrolase I:
GTP + H2O→7,8-dihydroneopterin 3'-triphosphate + formate + H+ (EC 3.5.4.16)
Synpcc7942_1597 (folE)
6-pyruvoyltetrahydropterin synthase:
7,8-dihydroneopterin 3'-triphosphate→(6R)-6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate (EC 4.2.3.12)
Synpcc7942_1184
Synpcc7942_1953
Sepiapterin reductase (in reverse):
(6R)-6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH + H+→(6R)-6-lactoyl-5,6,7,8-tetrahydropterin + NADP+ (EC 1.1.1.153; 1.1.1.220; 1.1.1.325)
Synpcc7942_1596 (acdS)
Sepiapterin reductase (in reverse):
(6R)-6-lactoyl-5,6,7,8-tetrahydropterin + NADPH + H+→(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP+ (EC 1.1.1.153)
Synpcc7942_1596 (acdS)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information