MetaCyc Pathway: L-tyrosine degradation I in Sinorhizobium meliloti 1021

MetaCyc Pathway: L-tyrosine degradation I in Sinorhizobium meliloti 1021

Aspartate transaminase:
L-tyrosine + 2-oxoglutarate→3-(4-hydroxyphenyl)pyruvate + L-glutamate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)

4-hydroxyphenylpyruvate dioxygenase:
3-(4-hydroxyphenyl)pyruvate + dioxygen→homogentisate + CO₂ (EC 1.13.11.27)

Homogentisate 1,2-dioxygenase:
homogentisate + dioxygen→4-maleyl-acetoacetate + H⁺ (EC 1.13.11.5)

Maleylacetoacetate isomerase:
4-maleyl-acetoacetate→4-fumaryl-acetoacetate (EC 5.2.1.2)

Fumarylacetoacetase:
4-fumaryl-acetoacetate + H₂O→acetoacetate + fumarate + H⁺ (EC 3.7.1.2)

Links:

Pathway details at MetaCyc
Fitness data for 21 genes
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All MetaCyc pathways for Sinorhizobium meliloti 1021

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information