MetaCyc Pathway: superpathway of L-serine and glycine biosynthesis I in Sinorhizobium meliloti 1021

MetaCyc Pathway: superpathway of L-serine and glycine biosynthesis I in Sinorhizobium meliloti 1021

Phosphoglycerate dehydrogenase:
3-phospho-D-glycerate + NAD⁺→3-phosphooxypyruvate + NADH + H⁺ (EC 1.1.1.95)

Phosphoserine transaminase (in reverse):
3-phosphooxypyruvate + L-glutamate→O-phospho-L-serine + 2-oxoglutarate (EC 2.6.1.52)

Phosphoserine phosphatase:
O-phospho-L-serine + H₂O→L-serine + phosphate (EC 3.1.3.3)

Glycine hydroxymethyltransferase:
L-serine + a tetrahydrofolate→glycine + a 5,10-methylenetetrahydrofolate + H₂O (EC 2.1.2.1)

Links:

Pathway details at MetaCyc
Fitness data for 16 genes
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All MetaCyc pathways for Sinorhizobium meliloti 1021

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information