MetaCyc Pathway: tetradecanoate biosynthesis (mitochondria) in Sinorhizobium meliloti 1021

MetaCyc Pathway: tetradecanoate biosynthesis (mitochondria) in Sinorhizobium meliloti 1021

3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
an acetoacetyl-[acp] + NADPH + H⁺→a (3R)-3-hydroxybutanoyl-[acp] + NADP⁺ (EC 1.1.1.100)

3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxybutanoyl-[acp]→a (2E)-but-2-enoyl-[acp] + H₂O (EC 4.2.1.59)

Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) (in reverse):
a (2E)-but-2-enoyl-[acp] + NADPH + H⁺→a butanoyl-[acp] + NADP⁺ (EC 1.3.1.10; 1.3.1.104; 1.3.1.39)

Beta-ketoacyl-acyl-carrier-protein synthase I:
a butanoyl-[acp] + malonyl-CoA + H⁺→a 3-oxohexanoyl-[acp] + CO₂ + coenzyme A (EC 2.3.1.41)

3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxohexanoyl-[acp] + NADPH + H⁺→a (3R)-3-hydroxyhexanoyl-[acp] + NADP⁺ (EC 1.1.1.100)

3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyhexanoyl-[acp]→a (2E)-hex-2-enoyl-[acp] + H₂O (EC 4.2.1.59)

Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) (in reverse):
a (2E)-hex-2-enoyl-[acp] + NADPH + H⁺→a hexanoyl-[acp] + NADP⁺ (EC 1.3.1.10; 1.3.1.104; 1.3.1.39)

Beta-ketoacyl-acyl-carrier-protein synthase I:
a hexanoyl-[acp] + malonyl-CoA + H⁺→a 3-oxooctanoyl-[acp] + CO₂ + coenzyme A (EC 2.3.1.41)

3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxooctanoyl-[acp] + NADPH + H⁺→a (3R)-3-hydroxyoctanoyl-[acp] + NADP⁺ (EC 1.1.1.100)

3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyoctanoyl-[acp]→a (2E)-oct-2-enoyl-[acp] + H₂O (EC 4.2.1.59)

Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) (in reverse):
a (2E)-oct-2-enoyl-[acp] + NADPH + H⁺→an octanoyl-[acp] + NADP⁺ (EC 1.3.1.10; 1.3.1.104; 1.3.1.39)

Beta-ketoacyl-acyl-carrier-protein synthase I:
an octanoyl-[acp] + malonyl-CoA + H⁺→a 3-oxodecanoyl-[acp] + CO₂ + coenzyme A (EC 2.3.1.41)

3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxodecanoyl-[acp] + NADPH + H⁺→a (3R)-3-hydroxydecanoyl-[acp] + NADP⁺ (EC 1.1.1.100)

3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxydecanoyl-[acp]→a (2E)-dec-2-enoyl-[acp] + H₂O (EC 4.2.1.59)

Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) (in reverse):
a (2E)-dec-2-enoyl-[acp] + NADPH + H⁺→a decanoyl-[acp] + NADP⁺ (EC 1.3.1.10; 1.3.1.104; 1.3.1.39)

Beta-ketoacyl-acyl-carrier-protein synthase I:
a decanoyl-[acp] + malonyl-CoA + H⁺→a 3-oxododecanoyl-[acp] + CO₂ + coenzyme A (EC 2.3.1.41)

3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxododecanoyl-[acp] + NADPH + H⁺→a (3R)-3-hydroxydodecanoyl-[acp] + NADP⁺ (EC 1.1.1.100)

3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxydodecanoyl-[acp]→a (2E)-dodec-2-enoyl-[acp] + H₂O (EC 4.2.1.59)

Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) (in reverse):
a (2E)-dodec-2-enoyl-[acp] + NADPH + H⁺→a dodecanoyl-[acp] + NADP⁺ (EC 1.3.1.10; 1.3.1.104; 1.3.1.39)

Dodecanoyl-[acyl-carrier-protein] hydrolase:
a dodecanoyl-[acp]_[nil] + H₂O_[nil]→laurate_[nil] + a soluble [acyl-carrier protein]_[nil] + H⁺_[nil] (EC 3.1.2.21)

No genes

Beta-ketoacyl-acyl-carrier-protein synthase I:
a dodecanoyl-[acp] + malonyl-CoA + H⁺→a 3-oxotetradecanoyl-[acp] + CO₂ + coenzyme A (EC 2.3.1.41)

3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxotetradecanoyl-[acp] + NADPH + H⁺→a (3R)-3-hydroxytetradecanoyl-[acp] + NADP⁺ (EC 1.1.1.100)

3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxytetradecanoyl-[acp]→a (2E)-tetradec-2-enoyl-[acp] + H₂O (EC 4.2.1.59)

Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) (in reverse):
a (2E)-tetradec-2-enoyl-[acp] + NADPH + H⁺→a myristoyl-[acp] + NADP⁺ (EC 1.3.1.10; 1.3.1.104; 1.3.1.39)

Oleoyl-[acyl-carrier-protein] hydrolase:
a myristoyl-[acp] + H₂O→tetradecanoate + a soluble [acyl-carrier protein] + H⁺ (EC 3.1.2.14)

No genes

Links:

Pathway details at MetaCyc
Fitness data for 41 genes
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All MetaCyc pathways for Sinorhizobium meliloti 1021

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information