MetaCyc Pathway: 8-amino-7-oxononanoate biosynthesis I in Sinorhizobium meliloti 1021

Add experiment(s):


a malonyl-[acp] + S-adenosyl-L-methionine→a malonyl-[acp] methyl ester + S-adenosyl-L-homocysteine (EC 2.1.1.197)
No genes
Beta-ketoacyl-acyl-carrier-protein synthase II:
a malonyl-[acp] + a malonyl-[acp] methyl ester + H+→a 3-oxoglutaryl-[acp] methyl ester + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
SMc00327
SMc00574
SMc04273
SMc04275
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxoglutaryl-[acp] methyl ester + NADPH + H+→a (3R)-3-hydroxyglutaryl-[acp] methyl ester + NADP+ (EC 1.1.1.100)
SM_b20073
SM_b20210
SM_b20493
SM_b20511
SM_b20871
SM_b21383
SM_b21474
SMa0059
SMa0074
SMa0187
SMa0329
SMa0335
SMa0389
SMa0854
SMa0959
SMa1367
SMa1398
SMa1629
SMa1967
SMa2019
SMa2165
SMc00136
SMc00260
SMc00264
SMc00268
SMc00372
SMc00572
SMc00778
SMc00880
SMc01157
SMc01571
SMc01991
SMc02037
SMc02041
SMc02522
SMc04391
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyglutaryl-[acp] methyl ester→a (2E)-enoylglutaryl-[acp] methyl ester + H2O (EC 4.2.1.59)
SMc00328
SMc02092
SMc04277
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-enoylglutaryl-[acp] methyl ester + NADH + H+→a glutaryl-[acp] methyl ester + NAD+ (EC 1.3.1.9)
SMc00005
SMc00326
Beta-ketoacyl-acyl-carrier-protein synthase II:
a glutaryl-[acp] methyl ester + a malonyl-[acp] + H+→a 3-oxopimeloyl-[acp] methyl ester + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
SMc00327
SMc00574
SMc04273
SMc04275
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxopimeloyl-[acp] methyl ester + NADPH + H+→a (3R)-3-hydroxypimeloyl-[acp] methyl ester + NADP+ (EC 1.1.1.100)
SM_b20073
SM_b20210
SM_b20493
SM_b20511
SM_b20871
SM_b21383
SM_b21474
SMa0059
SMa0074
SMa0187
SMa0329
SMa0335
SMa0389
SMa0854
SMa0959
SMa1367
SMa1398
SMa1629
SMa1967
SMa2019
SMa2165
SMc00136
SMc00260
SMc00264
SMc00268
SMc00372
SMc00572
SMc00778
SMc00880
SMc01157
SMc01571
SMc01991
SMc02037
SMc02041
SMc02522
SMc04391
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxypimeloyl-[acp] methyl ester→a (2E)-enoylpimeloyl-[acp] methyl ester + H2O (EC 4.2.1.59)
SMc00328
SMc02092
SMc04277
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-enoylpimeloyl-[acp] methyl ester + NADH + H+→a pimeloyl-[acp] methyl ester + NAD+ (EC 1.3.1.9)
SMc00005
SMc00326
a pimeloyl-[acp] methyl ester + H2O→a pimeloyl-[acp] + methanol + H+ (EC 3.1.1.85)
No genes
8-amino-7-oxononanoate synthase:
a pimeloyl-[acp] + L-alanine + H+→(8S)-8-amino-7-oxononanoate + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.47)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information