MetaCyc Pathway: purine nucleotides degradation II (aerobic) in Sinorhizobium meliloti 1021

MetaCyc Pathway: purine nucleotides degradation II (aerobic) in Sinorhizobium meliloti 1021

5'-nucleotidase:
AMP + H₂O→adenosine + phosphate (EC 3.1.3.5)

IMP dehydrogenase:
IMP + NAD⁺ + H₂O→XMP + NADH + H⁺ (EC 1.1.1.205)

5'-nucleotidase:
GMP + H₂O→guanosine + phosphate (EC 3.1.3.5)

Adenosine deaminase:
adenosine + H⁺ + H₂O→inosine + ammonium (EC 3.5.4.4)

Purine-nucleoside phosphorylase:
guanosine + phosphate→guanine + α-D-ribose-1-phosphate (EC 2.4.2.1; 2.4.2.15)

5'-nucleotidase:
XMP + H₂O→xanthosine + phosphate (EC 3.1.3.5)

Guanine deaminase:
guanine + H⁺ + H₂O→xanthine + ammonium (EC 3.5.4.3)

Purine-nucleoside phosphorylase:
inosine + phosphate→hypoxanthine + α-D-ribose-1-phosphate (EC 2.4.2.1)

Purine-nucleoside phosphorylase:
xanthosine + phosphate→xanthine + α-D-ribose-1-phosphate (EC 2.4.2.1)

Xanthine dehydrogenase:
hypoxanthine + NAD⁺ + H₂O→xanthine + NADH + H⁺ (EC 1.17.1.4)

Xanthine dehydrogenase:
xanthine + NAD⁺ + H₂O→urate + NADH + H⁺ (EC 1.17.1.4)

Links:

Pathway details at MetaCyc
Fitness data for 27 genes
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All MetaCyc pathways for Sinorhizobium meliloti 1021

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information