| a 5,10-methylenetetrahydrofolate + NADPH + H+→a 5-methyltetrahydrofolate + NADP+ (EC 1.5.1.53) |
| No genes |
| a 5,10-methylenetetrahydrofolate + NADH + H+→a 5-methyltetrahydrofolate + NAD+ (EC 1.5.1.54) |
| No genes |
Methylenetetrahydrofolate reductase (ferredoxin) (in reverse):
a 5,10-methylenetetrahydrofolate + 2 H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→a 5-methyltetrahydrofolate + 2 an oxidized ferredoxin [iron-sulfur] cluster (EC 1.5.7.1) |
| No genes |
Methionine synthase:
a 5-methyltetrahydrofolate + L-homocysteine→a tetrahydrofolate + L-methionine (EC 2.1.1.13) |
| SMc03112 |
| SMc04325 |
| SMc04331 |
| SMc04342 |
Glycine hydroxymethyltransferase:
a tetrahydrofolate + L-serine→a 5,10-methylenetetrahydrofolate + glycine + H2O (EC 2.1.2.1) |
| SMa2135 |
| SMc01770 |
5-formyltetrahydrofolate cyclo-ligase:
a (6S)-5-formyltetrahydrofolate + ATP→a 5,10-methenyltetrahydrofolate + ADP + phosphate (EC 6.3.3.2) |
| SMc02594 |
| SMc03974 |
| a 5,10-methylenetetrahydrofolate + ammonium + CO2 + NADH→a tetrahydrofolate + glycine + NAD+ (EC 1.4.1.27) |
| SMc02487 |
Methylenetetrahydrofolate dehydrogenase (NADP(+)):
a 5,10-methylenetetrahydrofolate + NADP+→a 5,10-methenyltetrahydrofolate + NADPH (EC 1.5.1.5) |
| SMc02604 |
| SMc03059 |
Methylenetetrahydrofolate dehydrogenase (NAD(+)):
a 5,10-methylenetetrahydrofolate + NAD+→a 5,10-methenyltetrahydrofolate + NADH (EC 1.5.1.15) |
| No genes |
Methylenetetrahydrofolate reductase (NAD(P)H) (in reverse):
a 5,10-methylenetetrahydrofolate + NAD(P)H + H+→a 5-methyltetrahydrofolate + NAD(P)+ (EC 1.5.1.20) |
| SMa2143 |
| SMc01843 |
| SMc04340 |
Methenyltetrahydrofolate cyclohydrolase:
a 5,10-methenyltetrahydrofolate + H2O→an N10-formyltetrahydrofolate + H+ (EC 3.5.4.9) |
| SMc02604 |
| SMc02728 |
| SMc03059 |
Formyltetrahydrofolate deformylase:
an N10-formyltetrahydrofolate + H2O→a tetrahydrofolate + formate + H+ (EC 3.5.1.10) |
| SMa2141 |
| SMc03205 |
| SMc04154 |
Formate--tetrahydrofolate ligase:
a tetrahydrofolate + ATP + formate→an N10-formyltetrahydrofolate + ADP + phosphate (EC 6.3.4.3) |
| SMc02728 |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information