MetaCyc Pathway: superpathway of methylglyoxal degradation in Sinorhizobium meliloti 1021

MetaCyc Pathway: superpathway of methylglyoxal degradation in Sinorhizobium meliloti 1021

Methylglyoxal reductase (NADPH-dependent) (in reverse):
methylglyoxal + NADPH + H⁺→(S)-lactaldehyde + NADP⁺ (EC 1.1.1.283)

Lactoylglutathione lyase (in reverse):
methylglyoxal + glutathione→(R)-S-lactoylglutathione (EC 4.4.1.5)

Aldehyde reductase (in reverse):
methylglyoxal + NADPH + H⁺→hydroxyacetone + NADP⁺ (EC 1.1.1.21)

Hydroxyacylglutathione hydrolase:
(R)-S-lactoylglutathione + H₂O→(R)-lactate + glutathione + H⁺ (EC 3.1.2.6)

Lactaldehyde dehydrogenase:
(S)-lactaldehyde + NAD⁺ + H₂O→(S)-lactate + NADH + 2 H⁺ (EC 1.2.1.22)

hydroxyacetone + NADH + H⁺→(S)-propane-1,2-diol + NAD⁺

(S)-lactate_[in] + an electron-transfer quinone→pyruvate_[in] + an electron-transfer quinol (EC 1.1.5.M6)

No genes

(R)-lactate_[in] + an electron-transfer quinone→pyruvate_[in] + an electron-transfer quinol (EC 1.1.5.12)

No genes

Links:

Pathway details at MetaCyc
Fitness data for 16 genes
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All MetaCyc pathways for Sinorhizobium meliloti 1021

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information